Synthesis of 1,3,4-Oxadiazole Derivatives Based on 2-[3-Alkyl-5(morpholinomethyl)-4,5-dihydro-1H-pyrazol-1-yl]-acetohydrazide
1
Institute of Polymer Materials of Ministry of Science and Education of the Azerbaijan Republic, Sumgayit, Azerbaijan
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Publication type: Journal Article
Publication date: 2025-08-01
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
Abstract
An efficient method was developed for the synthesis of fused nitrogen-containing heterocyclic compounds, such as 1,3,4-oxadiazole-substituted pyrazolines based on 3,5-disubstituted pyrazoline acylhydrazide. N′-Acetyl- and N′-chloroacetyl derivatives were obtained by acylation of previously synthesized 2-[3-methyl-5-(morpholinomethyl)pyrazoline]acetohydrazide with acetic and monochloroacetic acids chlorides. Intramolecular cyclization of the synthesized pyrazoline derivatives under the action of phosphorus chloride furnished 1,3,4-oxadiazole-substituted pyrazolines.
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Karayeva A. R. et al. Synthesis of 1,3,4-Oxadiazole Derivatives Based on 2-[3-Alkyl-5(morpholinomethyl)-4,5-dihydro-1H-pyrazol-1-yl]-acetohydrazide // Russian Journal of General Chemistry. 2025. Vol. 95. No. 8. pp. 2219-2224.
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Karayeva A. R., Shatirova M. I., Mamedova G. M., Sheydayeva S. K. Synthesis of 1,3,4-Oxadiazole Derivatives Based on 2-[3-Alkyl-5(morpholinomethyl)-4,5-dihydro-1H-pyrazol-1-yl]-acetohydrazide // Russian Journal of General Chemistry. 2025. Vol. 95. No. 8. pp. 2219-2224.
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TY - JOUR
DO - 10.1134/s1070363225603412
UR - https://link.springer.com/10.1134/S1070363225603412
TI - Synthesis of 1,3,4-Oxadiazole Derivatives Based on 2-[3-Alkyl-5(morpholinomethyl)-4,5-dihydro-1H-pyrazol-1-yl]-acetohydrazide
T2 - Russian Journal of General Chemistry
AU - Karayeva, A. R.
AU - Shatirova, M. I.
AU - Mamedova, G. M.
AU - Sheydayeva, Sh. K.
PY - 2025
DA - 2025/08/01
PB - Pleiades Publishing
SP - 2219-2224
IS - 8
VL - 95
SN - 1070-3632
SN - 1608-3350
ER -
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@article{2025_Karayeva,
author = {A. R. Karayeva and M. I. Shatirova and G. M. Mamedova and Sh. K. Sheydayeva},
title = {Synthesis of 1,3,4-Oxadiazole Derivatives Based on 2-[3-Alkyl-5(morpholinomethyl)-4,5-dihydro-1H-pyrazol-1-yl]-acetohydrazide},
journal = {Russian Journal of General Chemistry},
year = {2025},
volume = {95},
publisher = {Pleiades Publishing},
month = {aug},
url = {https://link.springer.com/10.1134/S1070363225603412},
number = {8},
pages = {2219--2224},
doi = {10.1134/s1070363225603412}
}
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MLA
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Karayeva, A. R., et al. “Synthesis of 1,3,4-Oxadiazole Derivatives Based on 2-[3-Alkyl-5(morpholinomethyl)-4,5-dihydro-1H-pyrazol-1-yl]-acetohydrazide.” Russian Journal of General Chemistry, vol. 95, no. 8, Aug. 2025, pp. 2219-2224. https://link.springer.com/10.1134/S1070363225603412.