Russian Journal of Organic Chemistry

, volume 53 , issue 7 , pages 977-980

Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors

G M Butov ¹

V V Burmistrov ¹

V S Dyachenko ¹

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Volzhskii Polytechnic Institute (Branch), Volgograd State Technical University, Volzhskii, Volgograd oblast, Russia |

Publication type: Journal Article

Publication date: 2017-07-01

Pleiades Publishing

Russian Journal of Organic Chemistry

scimago Q4

wos Q4

SJR: 0.190

CiteScore: 1.3

Impact factor: 0.9

ISSN: 10704280, 16083393

DOI: 10.1134/s107042801707003x

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Organic Chemistry

Abstract

Self-condensation of substituted adamantan-1-yl isocyanates in THF in the presence of DBU afforded 91–96% of symmetrical ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors. The described reaction avoids the use of the corresponding amine as counterpart. The obtained ureas are characterized by reduced melting points and improved solubility in water.

Found

12 citations

Burmistrov Vladimir

🥼 🤝

DSc in Chemistry, associate professor

86 publications, 607 citations

h-index: 13

Volgograd State Technical University

Research interests

Analytical Chemistry

Biochemistry

Gas chromatography (GS)

4 citations

Gladkih Boris

🤝

PhD in Chemistry

13 publications, 41 citations

h-index: 4

Volgograd State Technical University

Research interests

Antitumor drugs

Biologically active low molecular weight compounds

Small-molecule drug development

Synthetic Organic Chemistry

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Butov G. M., Burmistrov V. V., Dyachenko V. S. Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors // Russian Journal of Organic Chemistry. 2017. Vol. 53. No. 7. pp. 977-980.

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RIS Copy

TY - JOUR

DO - 10.1134/s107042801707003x

UR - https://doi.org/10.1134/s107042801707003x

TI - Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors

T2 - Russian Journal of Organic Chemistry

AU - Butov, G M

AU - Burmistrov, V V

AU - Dyachenko, V S

PY - 2017

DA - 2017/07/01

PB - Pleiades Publishing

SP - 977-980

IS - 7

VL - 53

SN - 1070-4280

SN - 1608-3393

ER -

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@article{2017_Butov,

author = {G M Butov and V V Burmistrov and V S Dyachenko},

title = {Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors},

journal = {Russian Journal of Organic Chemistry},

year = {2017},

volume = {53},

publisher = {Pleiades Publishing},

month = {jul},

url = {https://doi.org/10.1134/s107042801707003x},

number = {7},

pages = {977--980},

doi = {10.1134/s107042801707003x}

}

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Butov, G. M., et al. “Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors.” Russian Journal of Organic Chemistry, vol. 53, no. 7, Jul. 2017, pp. 977-980. https://doi.org/10.1134/s107042801707003x.