Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors
Тип публикации: Journal Article
Дата публикации: 2017-07-01
scimago Q4
wos Q4
БС3
SJR: 0.190
CiteScore: 1.3
Impact factor: 0.9
ISSN: 10704280, 16083393
Organic Chemistry
Краткое описание
Self-condensation of substituted adamantan-1-yl isocyanates in THF in the presence of DBU afforded 91–96% of symmetrical ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors. The described reaction avoids the use of the corresponding amine as counterpart. The obtained ureas are characterized by reduced melting points and improved solubility in water.
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Butov G. M., Burmistrov V. V., Dyachenko V. S. Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors // Russian Journal of Organic Chemistry. 2017. Vol. 53. No. 7. pp. 977-980.
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Butov G. M., Burmistrov V. V., Dyachenko V. S. Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors // Russian Journal of Organic Chemistry. 2017. Vol. 53. No. 7. pp. 977-980.
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TY - JOUR
DO - 10.1134/s107042801707003x
UR - https://doi.org/10.1134/s107042801707003x
TI - Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors
T2 - Russian Journal of Organic Chemistry
AU - Butov, G M
AU - Burmistrov, V V
AU - Dyachenko, V S
PY - 2017
DA - 2017/07/01
PB - Pleiades Publishing
SP - 977-980
IS - 7
VL - 53
SN - 1070-4280
SN - 1608-3393
ER -
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@article{2017_Butov,
author = {G M Butov and V V Burmistrov and V S Dyachenko},
title = {Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors},
journal = {Russian Journal of Organic Chemistry},
year = {2017},
volume = {53},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134/s107042801707003x},
number = {7},
pages = {977--980},
doi = {10.1134/s107042801707003x}
}
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MLA
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Butov, G. M., et al. “Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors.” Russian Journal of Organic Chemistry, vol. 53, no. 7, Jul. 2017, pp. 977-980. https://doi.org/10.1134/s107042801707003x.
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