5-(1,3-Benzothiazol-2-yl)furan-2-carbaldehyde in the Design of Antitumor Agents
1
Danilo Halytsky Lviv National Medical University, Lviv, Ukraine
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2
Ivan Franko Lviv National University, Lviv, Ukraine
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Publication type: Journal Article
Publication date: 2020-10-01
scimago Q4
wos Q4
SJR: 0.190
CiteScore: 1.3
Impact factor: 0.9
ISSN: 10704280, 16083393
Organic Chemistry
Abstract
Reactions of 5-(1,3-benzothiazol-2-yl)furan-2-carbaldehyde with 2-acetylfuran, 2-acetylthiophene, and some compounds containing an active methylene group gave a number of new 3-[5-(1,3-benzothiazol-2-yl)furan-2-yl]-1-(furan- or thiophen-2-yl)prop-2-en-1-one, 3-[5-(1,3-benzothiazol-2-yl)furan-2-yl]acrylonitrile, 3-[5-(1,3-benzothiazol-2-yl)furan-2-yl]-2-cyanoacrylamide, and 5-{[5-(1,3-benzothiazol-2-yl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one derivatives. 5-{[5-(1,3-Benzothiazol-2-yl)furan-2-yl]methylidene}-2-(morpholin-4-yl)-1,3-thiazol-4-one and diethyl 4-[5-(1,3-benzothiazol-2-yl)furan-2-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate were synthesized by multicomponent reactions involving the title compound. Antitumor screening of the synthesized 5-(1,3-benzothiazol-2-yl)furan-2-carbaldehyde derivatives revealed a lead compound, 3-[5-(1,3-benzothiazol-2-yl)furan-2-yl]-2-(4-phenyl-1,3-thiazol-2-yl)prop-2-enenitrile, which proved to be superior to 5-fluorouracil, cisplatin, and curcumin taken as reference drugs.
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Matiichuk Yu. E. et al. 5-(1,3-Benzothiazol-2-yl)furan-2-carbaldehyde in the Design of Antitumor Agents // Russian Journal of Organic Chemistry. 2020. Vol. 56. No. 10. pp. 1720-1727.
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Matiichuk Yu. E., Horak Y. I., Chaban T. I., Horishny V. Ya., Tymoshuk O. S., Matiychuk V. S. 5-(1,3-Benzothiazol-2-yl)furan-2-carbaldehyde in the Design of Antitumor Agents // Russian Journal of Organic Chemistry. 2020. Vol. 56. No. 10. pp. 1720-1727.
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TY - JOUR
DO - 10.1134/s1070428020100085
UR - https://doi.org/10.1134/s1070428020100085
TI - 5-(1,3-Benzothiazol-2-yl)furan-2-carbaldehyde in the Design of Antitumor Agents
T2 - Russian Journal of Organic Chemistry
AU - Matiichuk, Yu E
AU - Horak, Y I
AU - Chaban, T I
AU - Horishny, V Ya
AU - Tymoshuk, O S
AU - Matiychuk, V S
PY - 2020
DA - 2020/10/01
PB - Pleiades Publishing
SP - 1720-1727
IS - 10
VL - 56
SN - 1070-4280
SN - 1608-3393
ER -
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@article{2020_Matiichuk,
author = {Yu E Matiichuk and Y I Horak and T I Chaban and V Ya Horishny and O S Tymoshuk and V S Matiychuk},
title = {5-(1,3-Benzothiazol-2-yl)furan-2-carbaldehyde in the Design of Antitumor Agents},
journal = {Russian Journal of Organic Chemistry},
year = {2020},
volume = {56},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.1134/s1070428020100085},
number = {10},
pages = {1720--1727},
doi = {10.1134/s1070428020100085}
}
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MLA
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Matiichuk, Yu. E., et al. “5-(1,3-Benzothiazol-2-yl)furan-2-carbaldehyde in the Design of Antitumor Agents.” Russian Journal of Organic Chemistry, vol. 56, no. 10, Oct. 2020, pp. 1720-1727. https://doi.org/10.1134/s1070428020100085.