A Multicomponent Synthesis of 4H-Pyrido[1,2-a]pyrimidine-2-hydroxy-4-one Derivatives and Assessment of Their Antimicrobial Activity
2
Department of Biotechnology, Institute of Engineering and Technology, Lucknow, India
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Publication type: Journal Article
Publication date: 2021-02-01
scimago Q4
wos Q4
SJR: 0.190
CiteScore: 1.3
Impact factor: 0.9
ISSN: 10704280, 16083393
Organic Chemistry
Abstract
A highly efficient method for the multicomponent synthesis of substituted 4H-pyrido[1,2-a]pyrimidine-2-hydroxy-4-one derivatives, starting from 4H-pyrido[1,2-a]primidine-2-hydroxy-4-one, β-naphthol, and substituted aromatic aldehydes, in moderate to good yields has been developed. The structure of the pyridopyrimidine derivatives was established by spectral methods. In vitro antibacterial activity of the newly synthesized compounds was evaluated against highly pathogenic Gram-positive [Staphylococcus aureus (MTCC 96)] and Gram-negative [Pseudomonas aeruginosa (MTCC 424), Salmonella typhi (MTCC 537), Klebsiella pneumoniae (MTCC 424), Escherichia coli (MTCC 64) and Chromobacterium violaceum] bacteria.
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Devi P., Bishnoi A., Singh V. A Multicomponent Synthesis of 4H-Pyrido[1,2-a]pyrimidine-2-hydroxy-4-one Derivatives and Assessment of Their Antimicrobial Activity // Russian Journal of Organic Chemistry. 2021. Vol. 57. No. 2. pp. 265-271.
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Devi P., Bishnoi A., Singh V. A Multicomponent Synthesis of 4H-Pyrido[1,2-a]pyrimidine-2-hydroxy-4-one Derivatives and Assessment of Their Antimicrobial Activity // Russian Journal of Organic Chemistry. 2021. Vol. 57. No. 2. pp. 265-271.
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TY - JOUR
DO - 10.1134/s1070428021020184
UR - https://doi.org/10.1134/s1070428021020184
TI - A Multicomponent Synthesis of 4H-Pyrido[1,2-a]pyrimidine-2-hydroxy-4-one Derivatives and Assessment of Their Antimicrobial Activity
T2 - Russian Journal of Organic Chemistry
AU - Devi, P.
AU - Bishnoi, A
AU - Singh, V.
PY - 2021
DA - 2021/02/01
PB - Pleiades Publishing
SP - 265-271
IS - 2
VL - 57
SN - 1070-4280
SN - 1608-3393
ER -
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BibTex (up to 50 authors)
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@article{2021_Devi,
author = {P. Devi and A Bishnoi and V. Singh},
title = {A Multicomponent Synthesis of 4H-Pyrido[1,2-a]pyrimidine-2-hydroxy-4-one Derivatives and Assessment of Their Antimicrobial Activity},
journal = {Russian Journal of Organic Chemistry},
year = {2021},
volume = {57},
publisher = {Pleiades Publishing},
month = {feb},
url = {https://doi.org/10.1134/s1070428021020184},
number = {2},
pages = {265--271},
doi = {10.1134/s1070428021020184}
}
Cite this
MLA
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Devi, P., et al. “A Multicomponent Synthesis of 4H-Pyrido[1,2-a]pyrimidine-2-hydroxy-4-one Derivatives and Assessment of Their Antimicrobial Activity.” Russian Journal of Organic Chemistry, vol. 57, no. 2, Feb. 2021, pp. 265-271. https://doi.org/10.1134/s1070428021020184.