Design, Synthesis, Molecular Docking, and Anti-inflammatory Activity of 2-[(E)-{1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(hydroxyimino)methyl]phenol and {1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(2-hydroxyphenyl)methanone Derivatives
N R Darekar
1, 2
,
SUSHAMA J. TAKATE
2
,
Hemantkumar N Akolkar
3
,
Mubarak H Shaikh
1
,
V M Khedkar
4
,
Dipak Raut
5
,
S. D Mhaske
2, 6
1
P.G. and Research Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, Ahmednagar, India
|
2
P.G. and Research Department of Chemistry, New Arts, Science and Commerce College, Ahmednagar, India
|
3
Department of Chemistry, Abasaheb Marathe Arts and New Commerce, Science College, Rajapur, India
|
4
5
Department of Pharmacognosy, Amrutvahini College of Pharmacy, Sangamner, India
|
6
Department of Chemistry, Dadapatil Rajale Arts, Science and Commerce College, Adinathnagar, Ahmednagar, India
|
Publication type: Journal Article
Publication date: 2024-09-01
scimago Q4
wos Q4
SJR: 0.190
CiteScore: 1.3
Impact factor: 0.9
ISSN: 10704280, 16083393
Abstract
A series of {1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(2-hydroxyphenyl)methanones 5 were synthesized from 1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazine 3 and substituted 3-formylchromones 4. Compounds 5 were converted into 2-[(E)-{1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(hydroxyimino)methyl]phenols 6. The synthesized compounds were characterized by spectral techniques screened for their anti-inflammatory activity. Compounds 6c and 6e showed good percent inhibition of haemolysis when compared with the standard drug celecoxib. The molecular docking study explored the essential binding mode and possible thermodynamic interactions within the binding site of COX-2 enzyme.
Found
Nothing found, try to update filter.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
0
Total citations:
0
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Darekar N. R. et al. Design, Synthesis, Molecular Docking, and Anti-inflammatory Activity of 2-[(E)-{1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(hydroxyimino)methyl]phenol and {1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(2-hydroxyphenyl)methanone Derivatives // Russian Journal of Organic Chemistry. 2024. Vol. 60. No. 9. pp. 1818-1827.
GOST all authors (up to 50)
Copy
Darekar N. R., TAKATE S. J., Akolkar H. N., Shaikh M. H., Khedkar V. M., Raut D., Mhaske S. D. Design, Synthesis, Molecular Docking, and Anti-inflammatory Activity of 2-[(E)-{1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(hydroxyimino)methyl]phenol and {1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(2-hydroxyphenyl)methanone Derivatives // Russian Journal of Organic Chemistry. 2024. Vol. 60. No. 9. pp. 1818-1827.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/s1070428024090264
UR - https://link.springer.com/10.1134/S1070428024090264
TI - Design, Synthesis, Molecular Docking, and Anti-inflammatory Activity of 2-[(E)-{1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(hydroxyimino)methyl]phenol and {1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(2-hydroxyphenyl)methanone Derivatives
T2 - Russian Journal of Organic Chemistry
AU - Darekar, N R
AU - TAKATE, SUSHAMA J.
AU - Akolkar, Hemantkumar N
AU - Shaikh, Mubarak H
AU - Khedkar, V M
AU - Raut, Dipak
AU - Mhaske, S. D
PY - 2024
DA - 2024/09/01
PB - Pleiades Publishing
SP - 1818-1827
IS - 9
VL - 60
SN - 1070-4280
SN - 1608-3393
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2024_Darekar,
author = {N R Darekar and SUSHAMA J. TAKATE and Hemantkumar N Akolkar and Mubarak H Shaikh and V M Khedkar and Dipak Raut and S. D Mhaske},
title = {Design, Synthesis, Molecular Docking, and Anti-inflammatory Activity of 2-[(E)-{1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(hydroxyimino)methyl]phenol and {1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(2-hydroxyphenyl)methanone Derivatives},
journal = {Russian Journal of Organic Chemistry},
year = {2024},
volume = {60},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://link.springer.com/10.1134/S1070428024090264},
number = {9},
pages = {1818--1827},
doi = {10.1134/s1070428024090264}
}
Cite this
MLA
Copy
Darekar, N. R., et al. “Design, Synthesis, Molecular Docking, and Anti-inflammatory Activity of 2-[(E)-{1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(hydroxyimino)methyl]phenol and {1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(2-hydroxyphenyl)methanone Derivatives.” Russian Journal of Organic Chemistry, vol. 60, no. 9, Sep. 2024, pp. 1818-1827. https://link.springer.com/10.1134/S1070428024090264.