Pleiades Publishing
Doklady Biochemistry and Biophysics
,  volume 516 ,  issue 1 ,  pages 111-114

Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles

M V Filimonova 1, 2
, 
D.D. Kolmanovich 3, 4
, 
G V Tikhonowski 5
, 
D S Petrunya 4, 5
, 
P A Kotelnikova 6
, 
A A Shitova 1
, 
O V Soldatova 1
, 
A. S. Filimonov 1
, 
V A Rybachuk 1
, 
A O Kosachenko 1
, 
K A Nikolaev 1
, 
G A Demyashkin 1
, 
A. A. Popov 5
, 
M S Savinov 5
, 
A.L. Popov 3, 4
, 
I V Zelepukin 6
, 
A A Lipengolts 5, 7
, 
K. E. Shpakova 5, 7
, 
A.V. Kabashin 8
, 
S N Koryakin 1, 2
, 
S. M. Deyev 6
, 
I.N. Zavestovskaya 4, 5
1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
Publication type: Journal Article
Publication date: 2024-05-25
Pleiades Publishing
scimago Q3
wos Q4
SJR: 0.223
CiteScore: 1.5
Impact factor: 0.7
ISSN: 16076729, 16083091
Abstract
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.
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Filimonova M. V. et al. Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles // Doklady Biochemistry and Biophysics. 2024. Vol. 516. No. 1. pp. 111-114.
GOST all authors (up to 50) Copy
Filimonova M. V. et al. Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles // Doklady Biochemistry and Biophysics. 2024. Vol. 516. No. 1. pp. 111-114.
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RIS Copy
TY - JOUR
DO - 10.1134/s1607672924700819
UR - https://link.springer.com/10.1134/S1607672924700819
TI - Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles
T2 - Doklady Biochemistry and Biophysics
AU - Filimonova, M V
AU - Kolmanovich, D.D.
AU - Tikhonowski, G V
AU - Petrunya, D S
AU - Kotelnikova, P A
AU - Shitova, A A
AU - Soldatova, O V
AU - Filimonov, A. S.
AU - Rybachuk, V A
AU - Kosachenko, A O
AU - Nikolaev, K A
AU - Demyashkin, G A
AU - Popov, A. A.
AU - Savinov, M S
AU - Popov, A.L.
AU - Zelepukin, I V
AU - Lipengolts, A A
AU - Shpakova, K. E.
AU - Kabashin, A.V.
AU - Koryakin, S N
AU - Deyev, S. M.
AU - Zavestovskaya, I.N.
PY - 2024
DA - 2024/05/25
PB - Pleiades Publishing
SP - 111-114
IS - 1
VL - 516
PMID - 38795244
SN - 1607-6729
SN - 1608-3091
ER -
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BibTex (up to 50 authors) Copy
@article{2024_Filimonova,
author = {M V Filimonova and D.D. Kolmanovich and G V Tikhonowski and D S Petrunya and P A Kotelnikova and A A Shitova and O V Soldatova and A. S. Filimonov and V A Rybachuk and A O Kosachenko and K A Nikolaev and G A Demyashkin and A. A. Popov and M S Savinov and A.L. Popov and I V Zelepukin and A A Lipengolts and K. E. Shpakova and A.V. Kabashin and S N Koryakin and S. M. Deyev and I.N. Zavestovskaya and others},
title = {Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles},
journal = {Doklady Biochemistry and Biophysics},
year = {2024},
volume = {516},
publisher = {Pleiades Publishing},
month = {may},
url = {https://link.springer.com/10.1134/S1607672924700819},
number = {1},
pages = {111--114},
doi = {10.1134/s1607672924700819}
}
MLA
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Filimonova, M. V., et al. “Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles.” Doklady Biochemistry and Biophysics, vol. 516, no. 1, May. 2024, pp. 111-114. https://link.springer.com/10.1134/S1607672924700819.