Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

, volume 13 , issue 1 , pages 93-96

Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain

M I Airapetov ^{1, 2}

E A Sekste ¹

S O Eresko ³

E R Bychkov ¹

A. A. LEBEDEV ¹

P D Shabanov ^{1, 3, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

Institute of Experimental Medicine (IEM), St. Petersburg, Russia |

St. Petersburg State Medical Pediatric University, St. Petersburg, Russia |

St. Petersburg state University, St. Petersburg, Russia |

⁴

Kirov Military Medical Academy, St. Petersburg, Russia |

Publication type: Journal Article

Publication date: 2019-01-01

Pleiades Publishing

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

scimago Q4

wos Q4

SJR: 0.206

CiteScore: 1.0

Impact factor: 0.4

ISSN: 19907508, 19907516

DOI: 10.1134/s1990750819010025

Copy DOI

Biochemistry

Clinical Biochemistry

Molecular Medicine

Abstract

Orexin and its receptors are involved in mechanisms of pathological craving to alcohol. This study has shown that the mRNA level of the orexin receptor type 1 (OX1R) significantly decreased in the prefrontal cortex in the group of chronically alcoholized (for 6 months) rats compared with intact control. The same changes in the OX1R gene expression were observed on day 1 and day 7 of alcohol withdrawal after chronic alcoholization. On the contrary, in the hippocampus, the OX1R mRNA level increased on day 1 and day 7 of alcohol withdrawal. In the ventral tegmental area, the OX1R mRNA level remained unchanged on both day 1 and day 7 of alcohol withdrawal compared with the groups of chronic alcoholization and intact control. This suggests involvement of the prefrontal cortex and hippocampus in mechanisms mediating chronic alcohol intoxication.

Found

Top-30

Journals

	1
Medicine in Drug Discovery	Medicine in Drug Discovery, 1, 33.33% Medicine in Drug Discovery 1 publication, 33.33%
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 1, 33.33% Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 1 publication, 33.33%
Reviews on Clinical Pharmacology and Drug Therapy	Reviews on Clinical Pharmacology and Drug Therapy, 1, 33.33% Reviews on Clinical Pharmacology and Drug Therapy 1 publication, 33.33%
	1

Publishers

	1
Elsevier	Elsevier, 1, 33.33% Elsevier 1 publication, 33.33%
Pleiades Publishing	Pleiades Publishing, 1, 33.33% Pleiades Publishing 1 publication, 33.33%
Eco-Vector LLC	Eco-Vector LLC, 1, 33.33% Eco-Vector LLC 1 publication, 33.33%
	1

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Airapetov M. I. et al. Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain // Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2019. Vol. 13. No. 1. pp. 93-96.

GOST all authors (up to 50) Copy

Airapetov M. I., Sekste E. A., Eresko S. O., Bychkov E. R., LEBEDEV A. A., Shabanov P. D. Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain // Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2019. Vol. 13. No. 1. pp. 93-96.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1134/s1990750819010025

UR - https://doi.org/10.1134/s1990750819010025

TI - Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain

T2 - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

AU - Airapetov, M I

AU - Sekste, E A

AU - Eresko, S O

AU - Bychkov, E R

AU - LEBEDEV, A. A.

AU - Shabanov, P D

PY - 2019

DA - 2019/01/01

PB - Pleiades Publishing

SP - 93-96

IS - 1

VL - 13

SN - 1990-7508

SN - 1990-7516

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Airapetov,

author = {M I Airapetov and E A Sekste and S O Eresko and E R Bychkov and A. A. LEBEDEV and P D Shabanov},

title = {Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain},

journal = {Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry},

year = {2019},

volume = {13},

publisher = {Pleiades Publishing},

month = {jan},

url = {https://doi.org/10.1134/s1990750819010025},

number = {1},

pages = {93--96},

doi = {10.1134/s1990750819010025}

}

MLA

Cite this

MLA Copy

Airapetov, M. I., et al. “Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain.” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, vol. 13, no. 1, Jan. 2019, pp. 93-96. https://doi.org/10.1134/s1990750819010025.