Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, volume 13, issue 1, pages 93-96
Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain
Airapetov M I
1, 2
,
Sekste E A
1
,
Eresko S O
3
,
Bychkov E R
1
,
LEBEDEV A. A.
1
,
Shabanov P D
1, 3, 4
Publication type: Journal Article
Publication date: 2019-01-01
Quartile SCImago
Q4
Quartile WOS
—
Impact factor: 0.6
ISSN: 19907508, 19907516
Biochemistry
Clinical Biochemistry
Molecular Medicine
Abstract
Orexin and its receptors are involved in mechanisms of pathological craving to alcohol. This study has shown that the mRNA level of the orexin receptor type 1 (OX1R) significantly decreased in the prefrontal cortex in the group of chronically alcoholized (for 6 months) rats compared with intact control. The same changes in the OX1R gene expression were observed on day 1 and day 7 of alcohol withdrawal after chronic alcoholization. On the contrary, in the hippocampus, the OX1R mRNA level increased on day 1 and day 7 of alcohol withdrawal. In the ventral tegmental area, the OX1R mRNA level remained unchanged on both day 1 and day 7 of alcohol withdrawal compared with the groups of chronic alcoholization and intact control. This suggests involvement of the prefrontal cortex and hippocampus in mechanisms mediating chronic alcohol intoxication.
Citations by journals
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Medicine in Drug Discovery
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1 publication, 33.33%
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Citations by publishers
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Elsevier
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1 publication, 33.33%
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Pleiades Publishing
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1 publication, 33.33%
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Eco-Vector LLC
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Eco-Vector LLC
1 publication, 33.33%
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1
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Airapetov M. I. et al. Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain // Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2019. Vol. 13. No. 1. pp. 93-96.
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Airapetov M. I., Sekste E. A., Eresko S. O., Bychkov E. R., LEBEDEV A. A., Shabanov P. D. Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain // Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2019. Vol. 13. No. 1. pp. 93-96.
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TY - JOUR
DO - 10.1134/s1990750819010025
UR - https://doi.org/10.1134%2Fs1990750819010025
TI - Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain
T2 - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
AU - Airapetov, M I
AU - Sekste, E A
AU - Eresko, S O
AU - Bychkov, E R
AU - LEBEDEV, A. A.
AU - Shabanov, P D
PY - 2019
DA - 2019/01/01 00:00:00
PB - Pleiades Publishing
SP - 93-96
IS - 1
VL - 13
SN - 1990-7508
SN - 1990-7516
ER -
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@article{2019_Airapetov,
author = {M I Airapetov and E A Sekste and S O Eresko and E R Bychkov and A. A. LEBEDEV and P D Shabanov},
title = {Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain},
journal = {Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry},
year = {2019},
volume = {13},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134%2Fs1990750819010025},
number = {1},
pages = {93--96},
doi = {10.1134/s1990750819010025}
}
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Airapetov, M. I., et al. “Chronic Alcoholism Influences the mRNA Level of the Orexin Receptor Type 1 (OX1R) in Emotiogenic Structures of the Rat Brain.” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, vol. 13, no. 1, Jan. 2019, pp. 93-96. https://doi.org/10.1134%2Fs1990750819010025.
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