Pleiades Publishing
Applied Biochemistry and Microbiology
,  volume 57 ,  issue 9 ,  pages 939-948

Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus

V Yu Poshekhontseva 1, 2
, 
V V Fokina 1, 2
, 
S V Tarlachkov 1, 3
, 
A.V. Machulin 1
, 
A A Shutov 1, 2
, 
M V Donova 1, 2
1
 
2
 
Pharmins, Ltd, Pushchino, Russia | 
3
 
Publication type: Journal Article
Publication date: 2021-12-14
Pleiades Publishing
scimago Q3
wos Q4
SJR: 0.294
CiteScore: 1.7
Impact factor: 1.1
ISSN: 00036838, 16083024
Biochemistry
Applied Microbiology and Biotechnology
Abstract
The Streptomyces sp. VKM Ac-2618D strain has been identified, and its morphological and physiological features have been studied in relation to the production of the immunosuppressant tacrolimus. The phenotypic variability of the strain was analyzed, and a dissociant with a high level of tacrolimus production was selected. Based on a comprehensive study of morphological, physiological, and chemotaxonomic properties and on phylogenetic analysis, the strain was named Streptomyces tsukubensis VKM Ac-2618D. The strain genome contains the full version of the tacrolimus biosynthetic gene cluster. The advantages of fed-batch cultivation mode for tacrolimus biosynthesis are shown. The results broaden the understanding of the characteristics of polyketide biosynthesis and can be used in the development of technology for tacrolimus production.
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GOST Copy
Poshekhontseva V. Yu. et al. Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus // Applied Biochemistry and Microbiology. 2021. Vol. 57. No. 9. pp. 939-948.
GOST all authors (up to 50) Copy
Poshekhontseva V. Yu., Fokina V. V., Tarlachkov S. V., Machulin A., Shutov A. A., Donova M. V. Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus // Applied Biochemistry and Microbiology. 2021. Vol. 57. No. 9. pp. 939-948.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1134/S0003683821090064
UR - https://link.springer.com/10.1134/S0003683821090064
TI - Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus
T2 - Applied Biochemistry and Microbiology
AU - Poshekhontseva, V Yu
AU - Fokina, V V
AU - Tarlachkov, S V
AU - Machulin, A.V.
AU - Shutov, A A
AU - Donova, M V
PY - 2021
DA - 2021/12/14
PB - Pleiades Publishing
SP - 939-948
IS - 9
VL - 57
PMID - 34924587
SN - 0003-6838
SN - 1608-3024
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Poshekhontseva,
author = {V Yu Poshekhontseva and V V Fokina and S V Tarlachkov and A.V. Machulin and A A Shutov and M V Donova},
title = {Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus},
journal = {Applied Biochemistry and Microbiology},
year = {2021},
volume = {57},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://link.springer.com/10.1134/S0003683821090064},
number = {9},
pages = {939--948},
doi = {10.1134/S0003683821090064}
}
MLA
Cite this
MLA Copy
Poshekhontseva, V. Yu., et al. “Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus.” Applied Biochemistry and Microbiology, vol. 57, no. 9, Dec. 2021, pp. 939-948. https://link.springer.com/10.1134/S0003683821090064.