Pleiades Publishing
Applied Biochemistry and Microbiology
,  том 57 ,  издание 9 ,  страницы 939-948

Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus

V Yu Poshekhontseva 1, 2
, 
V V Fokina 1, 2
, 
S V Tarlachkov 1, 3
, 
A.V. Machulin 1
, 
A A Shutov 1, 2
, 
M V Donova 1, 2
1
 
2
 
Pharmins, Ltd, Pushchino, Russia | 
3
 
Тип публикации: Journal Article
Дата публикации: 2021-12-14
Pleiades Publishing
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SJR: 0.294
CiteScore: 1.7
Impact factor: 1.1
ISSN: 00036838, 16083024
Biochemistry
Applied Microbiology and Biotechnology
Краткое описание
The Streptomyces sp. VKM Ac-2618D strain has been identified, and its morphological and physiological features have been studied in relation to the production of the immunosuppressant tacrolimus. The phenotypic variability of the strain was analyzed, and a dissociant with a high level of tacrolimus production was selected. Based on a comprehensive study of morphological, physiological, and chemotaxonomic properties and on phylogenetic analysis, the strain was named Streptomyces tsukubensis VKM Ac-2618D. The strain genome contains the full version of the tacrolimus biosynthetic gene cluster. The advantages of fed-batch cultivation mode for tacrolimus biosynthesis are shown. The results broaden the understanding of the characteristics of polyketide biosynthesis and can be used in the development of technology for tacrolimus production.
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Poshekhontseva V. Yu. et al. Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus // Applied Biochemistry and Microbiology. 2021. Vol. 57. No. 9. pp. 939-948.
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Poshekhontseva V. Yu., Fokina V. V., Tarlachkov S. V., Machulin A., Shutov A. A., Donova M. V. Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus // Applied Biochemistry and Microbiology. 2021. Vol. 57. No. 9. pp. 939-948.
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TY - JOUR
DO - 10.1134/S0003683821090064
UR - https://link.springer.com/10.1134/S0003683821090064
TI - Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus
T2 - Applied Biochemistry and Microbiology
AU - Poshekhontseva, V Yu
AU - Fokina, V V
AU - Tarlachkov, S V
AU - Machulin, A.V.
AU - Shutov, A A
AU - Donova, M V
PY - 2021
DA - 2021/12/14
PB - Pleiades Publishing
SP - 939-948
IS - 9
VL - 57
PMID - 34924587
SN - 0003-6838
SN - 1608-3024
ER -
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@article{2021_Poshekhontseva,
author = {V Yu Poshekhontseva and V V Fokina and S V Tarlachkov and A.V. Machulin and A A Shutov and M V Donova},
title = {Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus},
journal = {Applied Biochemistry and Microbiology},
year = {2021},
volume = {57},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://link.springer.com/10.1134/S0003683821090064},
number = {9},
pages = {939--948},
doi = {10.1134/S0003683821090064}
}
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Poshekhontseva, V. Yu., et al. “Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus.” Applied Biochemistry and Microbiology, vol. 57, no. 9, Dec. 2021, pp. 939-948. https://link.springer.com/10.1134/S0003683821090064.