Pleiades Publishing
Biochemistry (Moscow)
,  том 71 ,  издание 9 ,  страницы 1021-1026

Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives

Тип публикации: Journal Article
Дата публикации: 2006-09-21
Pleiades Publishing
scimago Q2
wos Q4
БС2
SJR: 0.659
CiteScore: 3.8
Impact factor: 2.2
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Краткое описание
Pyrogallol reversibly and noncompetitively inhibits the activity of the hepatitis C RNA-dependent RNA polyme rase. Based on molecular modeling of the inhibitor binding in the active site of the enzyme, the inhibition was suggested to be realized via chelation of two magnesium cations involved in the catalysis at the stage of the phosphoryl residue transfer. The proposed model allowed us to purposefully synthesize new derivatives with higher inhibitory capacity.
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Kozlov M. V. et al. Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives // Biochemistry (Moscow). 2006. Vol. 71. No. 9. pp. 1021-1026.
ГОСТ со всеми авторами (до 50) Скопировать
Kozlov M. V., Polyakov K. M., A.V. I., Filippova S. E., Kuzyakin A. O., Tunitskaya V. L., Kochetkov S. N. Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives // Biochemistry (Moscow). 2006. Vol. 71. No. 9. pp. 1021-1026.
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TY - JOUR
DO - 10.1134/S0006297906090112
UR - https://doi.org/10.1134/S0006297906090112
TI - Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives
T2 - Biochemistry (Moscow)
AU - Kozlov, M. V.
AU - Polyakov, K. M.
AU - A.V., Ivanov
AU - Filippova, S E
AU - Kuzyakin, A O
AU - Tunitskaya, V L
AU - Kochetkov, S. N.
PY - 2006
DA - 2006/09/21
PB - Pleiades Publishing
SP - 1021-1026
IS - 9
VL - 71
PMID - 17009957
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2006_Kozlov,
author = {M. V. Kozlov and K. M. Polyakov and Ivanov A.V. and S E Filippova and A O Kuzyakin and V L Tunitskaya and S. N. Kochetkov},
title = {Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives},
journal = {Biochemistry (Moscow)},
year = {2006},
volume = {71},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134/S0006297906090112},
number = {9},
pages = {1021--1026},
doi = {10.1134/S0006297906090112}
}
MLA
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Kozlov, M. V., et al. “Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives.” Biochemistry (Moscow), vol. 71, no. 9, Sep. 2006, pp. 1021-1026. https://doi.org/10.1134/S0006297906090112.