Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives
Publication type: Journal Article
Publication date: 2006-09-21
scimago Q2
wos Q4
SJR: 0.659
CiteScore: 3.8
Impact factor: 2.2
ISSN: 00062979, 16083040
PubMed ID:
17009957
Biochemistry
General Medicine
Abstract
Pyrogallol reversibly and noncompetitively inhibits the activity of the hepatitis C RNA-dependent RNA polyme rase. Based on molecular modeling of the inhibitor binding in the active site of the enzyme, the inhibition was suggested to be realized via chelation of two magnesium cations involved in the catalysis at the stage of the phosphoryl residue transfer. The proposed model allowed us to purposefully synthesize new derivatives with higher inhibitory capacity.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
|
|
|
Biochemistry (Moscow)
1 publication, 25%
|
|
|
Sensors
1 publication, 25%
|
|
|
Biochimie
1 publication, 25%
|
|
|
Handbook of Experimental Pharmacology
1 publication, 25%
|
|
|
1
|
Publishers
|
1
|
|
|
Pleiades Publishing
1 publication, 25%
|
|
|
MDPI
1 publication, 25%
|
|
|
Elsevier
1 publication, 25%
|
|
|
Springer Nature
1 publication, 25%
|
|
|
1
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
4
Total citations:
4
Citations from 2024:
0
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Kozlov M. V. et al. Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives // Biochemistry (Moscow). 2006. Vol. 71. No. 9. pp. 1021-1026.
GOST all authors (up to 50)
Copy
Kozlov M. V., Polyakov K. M., A.V. I., Filippova S. E., Kuzyakin A. O., Tunitskaya V. L., Kochetkov S. N. Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives // Biochemistry (Moscow). 2006. Vol. 71. No. 9. pp. 1021-1026.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/S0006297906090112
UR - https://doi.org/10.1134/S0006297906090112
TI - Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives
T2 - Biochemistry (Moscow)
AU - Kozlov, M. V.
AU - Polyakov, K. M.
AU - A.V., Ivanov
AU - Filippova, S E
AU - Kuzyakin, A O
AU - Tunitskaya, V L
AU - Kochetkov, S. N.
PY - 2006
DA - 2006/09/21
PB - Pleiades Publishing
SP - 1021-1026
IS - 9
VL - 71
PMID - 17009957
SN - 0006-2979
SN - 1608-3040
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2006_Kozlov,
author = {M. V. Kozlov and K. M. Polyakov and Ivanov A.V. and S E Filippova and A O Kuzyakin and V L Tunitskaya and S. N. Kochetkov},
title = {Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives},
journal = {Biochemistry (Moscow)},
year = {2006},
volume = {71},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134/S0006297906090112},
number = {9},
pages = {1021--1026},
doi = {10.1134/S0006297906090112}
}
Cite this
MLA
Copy
Kozlov, M. V., et al. “Hepatitis C virus RNA-dependent RNA polymerase: Study on the inhibition mechanism by pyrogallol derivatives.” Biochemistry (Moscow), vol. 71, no. 9, Sep. 2006, pp. 1021-1026. https://doi.org/10.1134/S0006297906090112.