Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes
Тип публикации: Journal Article
Дата публикации: 2014-07-01
scimago Q2
wos Q4
white level БС2
SJR: 0.659
CiteScore: 3.8
Impact factor: 2.2
ISSN: 00062979, 16083040
PubMed ID:
25108326
Biochemistry
General Medicine
Краткое описание
Acetylation of α-tubulin was studied in cultures of human hepatocytes under the influence of selective inhibitors of histone deacetylases HDAC6 and SIRT-2 — tubastatin A and 2-(3-phenethoxyphenylamino)benzamide, respectively. It was found that in hepatocyte cell line HepG2 acetylated α-tubulin is accumulated preferentially on inhibition of HDAC6 but not of SIRT-2. Under the same conditions, no acetylation of α-tubulin was observed in hepatocyte cell line Huh7. However, the inhibition of HDAC6 with tubastatin A led to hyperacetylation of α-tubulin and simultaneously to decrease in viral RNA concentration in hepatocyte cell line Huh7-luc/neo, which supports propagation of the full genome replicon of hepatitis C virus. The correlation between these two processes points to HDAC6 as a promising cellular target for therapy of hepatitis C.
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ГОСТ
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Kozlov M. V. et al. Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes // Biochemistry (Moscow). 2014. Vol. 79. No. 7. pp. 637-642.
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Kozlov M. V., Kleymenova A. A., Konduktorov K. A., Malikova A. Z., Kochetkov S. N. Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes // Biochemistry (Moscow). 2014. Vol. 79. No. 7. pp. 637-642.
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TY - JOUR
DO - 10.1134/S0006297914070050
UR - https://doi.org/10.1134/S0006297914070050
TI - Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes
T2 - Biochemistry (Moscow)
AU - Kozlov, M. V.
AU - Kleymenova, A A
AU - Konduktorov, K A
AU - Malikova, A Z
AU - Kochetkov, S. N.
PY - 2014
DA - 2014/07/01
PB - Pleiades Publishing
SP - 637-642
IS - 7
VL - 79
PMID - 25108326
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2014_Kozlov,
author = {M. V. Kozlov and A A Kleymenova and K A Konduktorov and A Z Malikova and S. N. Kochetkov},
title = {Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes},
journal = {Biochemistry (Moscow)},
year = {2014},
volume = {79},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134/S0006297914070050},
number = {7},
pages = {637--642},
doi = {10.1134/S0006297914070050}
}
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MLA
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Kozlov, M. V., et al. “Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes.” Biochemistry (Moscow), vol. 79, no. 7, Jul. 2014, pp. 637-642. https://doi.org/10.1134/S0006297914070050.
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