Pleiades Publishing
Biochemistry (Moscow)
,  volume 84 ,  issue 1 ,  pages 1-10

Mechanisms of Leptin and Ghrelin Action on Maturation and Functions of Dendritic Cells

Publication type: Journal Article
Publication date: 2019-01-01
Pleiades Publishing
scimago Q2
wos Q4
SJR: 0.659
CiteScore: 3.8
Impact factor: 2.2
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Abstract
Molecular mechanisms of the immunomodulatory effects of leptin and ghrelin in concentrations typical for preg–nancy on the maturation and functional activity of dendritic cells (DCs) generated from the peripheral blood monocytes of women are investigated. The presence of leptin during DC maturation did not affect the levels of CD83+CD1c+, CD86+CD1c+, and HLA–DR+CD1c+ DCs, but increased the amount and the activity of the enzyme indoleamine 2,3–dioxygenase (IDO). Cell culturing in the presence of ghrelin or combination of leptin and ghrelin reduced the percentage of CD86+CD1c+ DCs but did not affect the levels of CD83+CD1c+ and HLA–DR+CD1c+ DCs. In addition, ghrelin reduced the number of IDO molecules without affecting its activity. Simultaneous presence of leptin and ghrelin increased induced IDO activity without affecting the amount of the enzyme in DCs. The effects of leptin and ghrelin on the investi–gated functions of DCs in some cases correlated with high levels of cAMP. New mechanisms for leptin and ghrelin regula–tion of tolerogenic functions of DCs in pregnancy are proposed.
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Orlova E. G., Shirshev S. V., Loginova O. A. Mechanisms of Leptin and Ghrelin Action on Maturation and Functions of Dendritic Cells // Biochemistry (Moscow). 2019. Vol. 84. No. 1. pp. 1-10.
GOST all authors (up to 50) Copy
Orlova E. G., Shirshev S. V., Loginova O. A. Mechanisms of Leptin and Ghrelin Action on Maturation and Functions of Dendritic Cells // Biochemistry (Moscow). 2019. Vol. 84. No. 1. pp. 1-10.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/S0006297919010012
UR - https://doi.org/10.1134/S0006297919010012
TI - Mechanisms of Leptin and Ghrelin Action on Maturation and Functions of Dendritic Cells
T2 - Biochemistry (Moscow)
AU - Orlova, E. G.
AU - Shirshev, S. V.
AU - Loginova, O A
PY - 2019
DA - 2019/01/01
PB - Pleiades Publishing
SP - 1-10
IS - 1
VL - 84
PMID - 30927520
SN - 0006-2979
SN - 1608-3040
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2019_Orlova,
author = {E. G. Orlova and S. V. Shirshev and O A Loginova},
title = {Mechanisms of Leptin and Ghrelin Action on Maturation and Functions of Dendritic Cells},
journal = {Biochemistry (Moscow)},
year = {2019},
volume = {84},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134/S0006297919010012},
number = {1},
pages = {1--10},
doi = {10.1134/S0006297919010012}
}
MLA
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MLA Copy
Orlova, E. G., et al. “Mechanisms of Leptin and Ghrelin Action on Maturation and Functions of Dendritic Cells.” Biochemistry (Moscow), vol. 84, no. 1, Jan. 2019, pp. 1-10. https://doi.org/10.1134/S0006297919010012.