Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes.
O Yu Kochetkova
1, 2
,
M M Yurinskaya
1
,
M.B. Evgen'ev
1, 3
,
O. G. Zatsepina
3
,
L.I. Shabarchina
2
,
A V Suslikov
4
,
S. A. Tikhonenko
2
,
M G Vinokurov
1
Publication type: Journal Article
Publication date: 2015-11-01
scimago Q3
SJR: 0.265
CiteScore: 1.2
Impact factor: —
ISSN: 00124966, 16083105
PubMed ID:
26725241
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Agricultural and Biological Sciences
General Immunology and Microbiology
Abstract
Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.
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Kochetkova O. Yu. et al. Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes. // Doklady Biological Sciences. 2015. Vol. 465. No. 1. pp. 299-302.
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Kochetkova O. Yu., Yurinskaya M. M., Evgen'ev M., Zatsepina O. G., Shabarchina L., Suslikov A. V., Tikhonenko S. A., Vinokurov M. G. Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes. // Doklady Biological Sciences. 2015. Vol. 465. No. 1. pp. 299-302.
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TY - JOUR
DO - 10.1134/S001249661506006X
UR - http://link.springer.com/10.1134/S001249661506006X
TI - Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes.
T2 - Doklady Biological Sciences
AU - Kochetkova, O Yu
AU - Yurinskaya, M M
AU - Evgen'ev, M.B.
AU - Zatsepina, O. G.
AU - Shabarchina, L.I.
AU - Suslikov, A V
AU - Tikhonenko, S. A.
AU - Vinokurov, M G
PY - 2015
DA - 2015/11/01
PB - Pleiades Publishing
SP - 299-302
IS - 1
VL - 465
PMID - 26725241
SN - 0012-4966
SN - 1608-3105
ER -
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BibTex (up to 50 authors)
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@article{2015_Kochetkova,
author = {O Yu Kochetkova and M M Yurinskaya and M.B. Evgen'ev and O. G. Zatsepina and L.I. Shabarchina and A V Suslikov and S. A. Tikhonenko and M G Vinokurov},
title = {Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes.},
journal = {Doklady Biological Sciences},
year = {2015},
volume = {465},
publisher = {Pleiades Publishing},
month = {nov},
url = {http://link.springer.com/10.1134/S001249661506006X},
number = {1},
pages = {299--302},
doi = {10.1134/S001249661506006X}
}
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Kochetkova, O. Yu., et al. “Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes..” Doklady Biological Sciences, vol. 465, no. 1, Nov. 2015, pp. 299-302. http://link.springer.com/10.1134/S001249661506006X.
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