Role of the pregnancy-specific glycoprotein in regulation of the cytokine and chemokine profiles of intact mononuclear cells
M.B Rayev
1, 2
,
L. S. Litvinova
3
,
K A Yurova
3
,
N A Dunets
3
,
O G Khaziakhmatova
3
,
V P Timganova
1
,
M S Bochkova
1
,
P V Khramtsov
1
,
S. A. Zamorina
1
Тип публикации: Journal Article
Дата публикации: 2017-07-01
scimago Q3
БС2
SJR: 0.265
CiteScore: 1.2
Impact factor: —
ISSN: 00124966, 16083105
PubMed ID:
28861873
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Agricultural and Biological Sciences
General Immunology and Microbiology
Краткое описание
The effect of human pregnancy-specific glycoprotein (PSG) on the cytokine and chemokine production in vitro by intact mononuclear cells was studied by the method of flow fluorimetry. PSG inhibited production of the proinflammatory cytokines IL-6, IL-8, IL-17, IFN-γ, and TNF-α and chemokines CCL3/MIP-1α, CCL4/MIP-1β, CCL2/MCP-1; at the same time, PSG stimulated IL-12(p70) production. Simultaneously with increasing the VEGF level, PSG inhibited production of IL-9, IL-13, G-CSF, and GM-CSF. The PSG effect discovered can be interpreted as a contribution into the immune tolerance formation during pregnancy.
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Rayev M. et al. Role of the pregnancy-specific glycoprotein in regulation of the cytokine and chemokine profiles of intact mononuclear cells // Doklady Biological Sciences. 2017. Vol. 475. No. 1. pp. 180-182.
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Rayev M., Litvinova L. S., Yurova K. A., Dunets N. A., Khaziakhmatova O. G., Timganova V. P., Bochkova M. S., Khramtsov P. V., Zamorina S. A. Role of the pregnancy-specific glycoprotein in regulation of the cytokine and chemokine profiles of intact mononuclear cells // Doklady Biological Sciences. 2017. Vol. 475. No. 1. pp. 180-182.
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TY - JOUR
DO - 10.1134/S001249661704007X
UR - https://doi.org/10.1134/S001249661704007X
TI - Role of the pregnancy-specific glycoprotein in regulation of the cytokine and chemokine profiles of intact mononuclear cells
T2 - Doklady Biological Sciences
AU - Rayev, M.B
AU - Litvinova, L. S.
AU - Yurova, K A
AU - Dunets, N A
AU - Khaziakhmatova, O G
AU - Timganova, V P
AU - Bochkova, M S
AU - Khramtsov, P V
AU - Zamorina, S. A.
PY - 2017
DA - 2017/07/01
PB - Pleiades Publishing
SP - 180-182
IS - 1
VL - 475
PMID - 28861873
SN - 0012-4966
SN - 1608-3105
ER -
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@article{2017_Rayev,
author = {M.B Rayev and L. S. Litvinova and K A Yurova and N A Dunets and O G Khaziakhmatova and V P Timganova and M S Bochkova and P V Khramtsov and S. A. Zamorina},
title = {Role of the pregnancy-specific glycoprotein in regulation of the cytokine and chemokine profiles of intact mononuclear cells},
journal = {Doklady Biological Sciences},
year = {2017},
volume = {475},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134/S001249661704007X},
number = {1},
pages = {180--182},
doi = {10.1134/S001249661704007X}
}
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MLA
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Rayev, M.B, et al. “Role of the pregnancy-specific glycoprotein in regulation of the cytokine and chemokine profiles of intact mononuclear cells.” Doklady Biological Sciences, vol. 475, no. 1, Jul. 2017, pp. 180-182. https://doi.org/10.1134/S001249661704007X.
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