Role of α-fetoprotein in differentiation of regulatory T lymphocytes
V. A. Chereshnev
1, 2, 3
,
V P Timganova
1
,
S. A. Zamorina
1, 2
,
M S Bochkova
1
,
P V Khramtsov
1, 2
,
M. D. Kropaneva
2
,
M B Raev
1, 2, 3
Publication type: Journal Article
Publication date: 2017-11-01
scimago Q3
SJR: 0.265
CiteScore: 1.2
Impact factor: —
ISSN: 00124966, 16083105
PubMed ID:
29299806
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Agricultural and Biological Sciences
General Immunology and Microbiology
Abstract
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4+ lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4+ cells. In the study of Treg differentiation, it was found that AFP at concentrations of 50 and 100 μg/mL significantly inhibited the number of nonproliferating CD4+FOXP3+ and CD4+FOXP3+HELIOS+ lymphocytes without affecting the expression of Treg markers by proliferating CD4+ lymphocytes.
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Chereshnev V. A. et al. Role of α-fetoprotein in differentiation of regulatory T lymphocytes // Doklady Biological Sciences. 2017. Vol. 477. No. 1. pp. 248-251.
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Chereshnev V. A., Timganova V. P., Zamorina S. A., Bochkova M. S., Khramtsov P. V., Kropaneva M. D., Raev M. B. Role of α-fetoprotein in differentiation of regulatory T lymphocytes // Doklady Biological Sciences. 2017. Vol. 477. No. 1. pp. 248-251.
Cite this
RIS
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TY - JOUR
DO - 10.1134/S0012496617060084
UR - https://doi.org/10.1134/S0012496617060084
TI - Role of α-fetoprotein in differentiation of regulatory T lymphocytes
T2 - Doklady Biological Sciences
AU - Chereshnev, V. A.
AU - Timganova, V P
AU - Zamorina, S. A.
AU - Bochkova, M S
AU - Khramtsov, P V
AU - Kropaneva, M. D.
AU - Raev, M B
PY - 2017
DA - 2017/11/01
PB - Pleiades Publishing
SP - 248-251
IS - 1
VL - 477
PMID - 29299806
SN - 0012-4966
SN - 1608-3105
ER -
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BibTex (up to 50 authors)
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@article{2017_Chereshnev,
author = {V. A. Chereshnev and V P Timganova and S. A. Zamorina and M S Bochkova and P V Khramtsov and M. D. Kropaneva and M B Raev},
title = {Role of α-fetoprotein in differentiation of regulatory T lymphocytes},
journal = {Doklady Biological Sciences},
year = {2017},
volume = {477},
publisher = {Pleiades Publishing},
month = {nov},
url = {https://doi.org/10.1134/S0012496617060084},
number = {1},
pages = {248--251},
doi = {10.1134/S0012496617060084}
}
Cite this
MLA
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Chereshnev, V. A., et al. “Role of α-fetoprotein in differentiation of regulatory T lymphocytes.” Doklady Biological Sciences, vol. 477, no. 1, Nov. 2017, pp. 248-251. https://doi.org/10.1134/S0012496617060084.