New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger
M. V. Kondashevskaya
1
,
M. V. Komelkova
2, 3
,
V E Tseilikman
2
,
O B Tseilikman
2, 3
,
K A Artemyeva
1
,
V V Aleksankina
1
,
M N Boltovskaya
1
,
A. P. Sarapultsev
2, 4
,
P N Popkov
5
,
M. V. Chereshneva
4
,
V. A. Chereshnev
4
Publication type: Journal Article
Publication date: 2021-11-01
scimago Q3
SJR: 0.265
CiteScore: 1.2
Impact factor: —
ISSN: 00124966, 16083105
PubMed ID:
34962605
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Agricultural and Biological Sciences
General Immunology and Microbiology
Abstract
For the first time in modeling posttraumatic stress disorder (PTSD), we have described the morphofunctional state of adrenal glands in Wistar rats resistant and sensitive to predator stress (rodent fear of the predator). Despite the evident signs of adrenal dysfunction in both phenotypes, we have discovered the thickening of undifferentiated cell zone and high indices of functional activity of stem cells in resistant animals, suggesting ample adaptation. The most important data demonstrate the direct relationship between the reduction of corticosterone and testosterone levels and adrenal dysfunction in PTSD models. The study results allow considering the adrenal stem cells as potential therapeutic targets.
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Total citations:
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Citations from 2025:
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(33.33%)
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GOST
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Kondashevskaya M. V. et al. New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger // Doklady Biological Sciences. 2021. Vol. 501. No. 1. pp. 192-196.
GOST all authors (up to 50)
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Kondashevskaya M. V., Komelkova M. V., Tseilikman V. E., Tseilikman O. B., Artemyeva K. A., Aleksankina V. V., Boltovskaya M. N., Sarapultsev A. P., Popkov P. N., Chereshneva M. V., Chereshnev V. A. New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger // Doklady Biological Sciences. 2021. Vol. 501. No. 1. pp. 192-196.
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RIS
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TY - JOUR
DO - 10.1134/S0012496621060028
UR - https://link.springer.com/10.1134/S0012496621060028
TI - New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger
T2 - Doklady Biological Sciences
AU - Kondashevskaya, M. V.
AU - Komelkova, M. V.
AU - Tseilikman, V E
AU - Tseilikman, O B
AU - Artemyeva, K A
AU - Aleksankina, V V
AU - Boltovskaya, M N
AU - Sarapultsev, A. P.
AU - Popkov, P N
AU - Chereshneva, M. V.
AU - Chereshnev, V. A.
PY - 2021
DA - 2021/11/01
PB - Pleiades Publishing
SP - 192-196
IS - 1
VL - 501
PMID - 34962605
SN - 0012-4966
SN - 1608-3105
ER -
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BibTex (up to 50 authors)
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@article{2021_Kondashevskaya,
author = {M. V. Kondashevskaya and M. V. Komelkova and V E Tseilikman and O B Tseilikman and K A Artemyeva and V V Aleksankina and M N Boltovskaya and A. P. Sarapultsev and P N Popkov and M. V. Chereshneva and V. A. Chereshnev},
title = {New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger},
journal = {Doklady Biological Sciences},
year = {2021},
volume = {501},
publisher = {Pleiades Publishing},
month = {nov},
url = {https://link.springer.com/10.1134/S0012496621060028},
number = {1},
pages = {192--196},
doi = {10.1134/S0012496621060028}
}
Cite this
MLA
Copy
Kondashevskaya, M. V., et al. “New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger.” Doklady Biological Sciences, vol. 501, no. 1, Nov. 2021, pp. 192-196. https://link.springer.com/10.1134/S0012496621060028.
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