Pleiades Publishing
Doklady Chemistry
,  том 513 ,  издание 2 ,  страницы 367-374

Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid

Тип публикации: Journal Article
Дата публикации: 2023-12-01
Pleiades Publishing
SCImago Q4
WOS Q4
БС3
SJR: 0.189
CiteScore: 1.3
Impact factor: 1
ISSN: 00125008, 16083113
General Chemistry
Краткое описание
Previously unknown phenyl-substituted iodo-δ-lactone derived from 11‑phenylundeca-5Z,9Z-dienoic acid was synthesized in 94% yield using the Ti-catalyzed intermolecular cross-cyclomagnesiation of aromatic 1,2-diene with O‑containing allene at the key stage. The in vitro cytotoxic activity of synthesized alkyl- and phenyl-substituted iodo-δ-lactones of 5Z,9Z-dienoic acids against the Jurkat, K562, U937, HL60, and Hek293 cell lines was studied, and their effect on the cell cycle and the ability to induce apoptosis were investigated using flow cytometry.
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Makarova E. Kh. et al. Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid // Doklady Chemistry. 2023. Vol. 513. No. 2. pp. 367-374.
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Makarova E. Kh., Ishbulatov I. V., Makarov A. A., Dzhemileva L. U., Dzhemilev U. M., Dyakonov V. A. Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid // Doklady Chemistry. 2023. Vol. 513. No. 2. pp. 367-374.
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TY - JOUR
DO - 10.1134/s0012500823700209
UR - https://link.springer.com/10.1134/S0012500823700209
TI - Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid
T2 - Doklady Chemistry
AU - Makarova, E Kh
AU - Ishbulatov, I. V.
AU - Makarov, A. A.
AU - Dzhemileva, L U
AU - Dzhemilev, U M
AU - Dyakonov, V A
PY - 2023
DA - 2023/12/01
PB - Pleiades Publishing
SP - 367-374
IS - 2
VL - 513
SN - 0012-5008
SN - 1608-3113
ER -
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@article{2023_Makarova,
author = {E Kh Makarova and I. V. Ishbulatov and A. A. Makarov and L U Dzhemileva and U M Dzhemilev and V A Dyakonov},
title = {Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid},
journal = {Doklady Chemistry},
year = {2023},
volume = {513},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://link.springer.com/10.1134/S0012500823700209},
number = {2},
pages = {367--374},
doi = {10.1134/s0012500823700209}
}
MLA
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MLA Скопировать
Makarova, E. Kh., et al. “Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid.” Doklady Chemistry, vol. 513, no. 2, Dec. 2023, pp. 367-374. https://link.springer.com/10.1134/S0012500823700209.
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