Pleiades Publishing
Doklady Chemistry
,  volume 513 ,  issue 2 ,  pages 367-374

Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid

Publication type: Journal Article
Publication date: 2023-12-01
Pleiades Publishing
scimago Q3
wos Q4
SJR: 0.205
CiteScore: 1.3
Impact factor: 1.0
ISSN: 00125008, 16083113
General Chemistry
Abstract
Previously unknown phenyl-substituted iodo-δ-lactone derived from 11‑phenylundeca-5Z,9Z-dienoic acid was synthesized in 94% yield using the Ti-catalyzed intermolecular cross-cyclomagnesiation of aromatic 1,2-diene with O‑containing allene at the key stage. The in vitro cytotoxic activity of synthesized alkyl- and phenyl-substituted iodo-δ-lactones of 5Z,9Z-dienoic acids against the Jurkat, K562, U937, HL60, and Hek293 cell lines was studied, and their effect on the cell cycle and the ability to induce apoptosis were investigated using flow cytometry.
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Makarova E. Kh. et al. Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid // Doklady Chemistry. 2023. Vol. 513. No. 2. pp. 367-374.
GOST all authors (up to 50) Copy
Makarova E. Kh., Ishbulatov I. V., Makarov A. A., Dzhemileva L. U., Dzhemilev U. M., Dyakonov V. A. Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid // Doklady Chemistry. 2023. Vol. 513. No. 2. pp. 367-374.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/s0012500823700209
UR - https://link.springer.com/10.1134/S0012500823700209
TI - Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid
T2 - Doklady Chemistry
AU - Makarova, E Kh
AU - Ishbulatov, I. V.
AU - Makarov, A. A.
AU - Dzhemileva, L U
AU - Dzhemilev, U M
AU - Dyakonov, V A
PY - 2023
DA - 2023/12/01
PB - Pleiades Publishing
SP - 367-374
IS - 2
VL - 513
SN - 0012-5008
SN - 1608-3113
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Makarova,
author = {E Kh Makarova and I. V. Ishbulatov and A. A. Makarov and L U Dzhemileva and U M Dzhemilev and V A Dyakonov},
title = {Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid},
journal = {Doklady Chemistry},
year = {2023},
volume = {513},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://link.springer.com/10.1134/S0012500823700209},
number = {2},
pages = {367--374},
doi = {10.1134/s0012500823700209}
}
MLA
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MLA Copy
Makarova, E. Kh., et al. “Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid.” Doklady Chemistry, vol. 513, no. 2, Dec. 2023, pp. 367-374. https://link.springer.com/10.1134/S0012500823700209.