Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs
A N Korovina
1
,
A A Guskova
2
,
M Yu Skoblov
2
,
V L Andronova
3
,
G A Galegov
3
,
S. N. Kochetkov
1
,
M K Kukhanova
1
,
Yu S Skoblov
4
Publication type: Journal Article
Publication date: 2010-06-26
scimago Q3
wos Q4
SJR: 0.331
CiteScore: 1.6
Impact factor: 1.2
ISSN: 00268933, 16083245, 21689547
PubMed ID:
20608166
Structural Biology
Biophysics
Abstract
Primary structures of DNA polymerase (ul30) and thymidine kinase (ul23) genes from several herpes simplex virus type 1 (HSV-1) clinical isolates di ffering in sensitivity to several antiherpetic drugs were determined and compared to those of two laboratory HSV-1 strains one of which (L2) was sensitive and the other (L2/R) was resistant to acyclovir. The phylogenetic sequence analysis showed that the ul30 and ul23 sequences of clinical isolates were close to those of L2, and that ul30 conserved regions differed between HSV-1 isolates and L2 only in point mutations and degenerated substitutions. Several new mutations in the HSV-1 DNA polymerase and thymidine kinase functional domains were identified as substitutions associated with strain resistance to ACV and other antiherpetic drugs.
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GOST
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Korovina A. N. et al. Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs // Molecular Biology. 2010. Vol. 44. No. 3. pp. 431-438.
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Korovina A. N., Guskova A. A., Skoblov M. Yu., Andronova V. L., Galegov G. A., Kochetkov S. N., Kukhanova M. K., Skoblov Yu. S. Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs // Molecular Biology. 2010. Vol. 44. No. 3. pp. 431-438.
Cite this
RIS
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TY - JOUR
DO - 10.1134/S0026893310030118
UR - https://doi.org/10.1134/S0026893310030118
TI - Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs
T2 - Molecular Biology
AU - Korovina, A N
AU - Guskova, A A
AU - Skoblov, M Yu
AU - Andronova, V L
AU - Galegov, G A
AU - Kochetkov, S. N.
AU - Kukhanova, M K
AU - Skoblov, Yu S
PY - 2010
DA - 2010/06/26
PB - Pleiades Publishing
SP - 431-438
IS - 3
VL - 44
PMID - 20608166
SN - 0026-8933
SN - 1608-3245
SN - 2168-9547
ER -
Cite this
BibTex (up to 50 authors)
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@article{2010_Korovina,
author = {A N Korovina and A A Guskova and M Yu Skoblov and V L Andronova and G A Galegov and S. N. Kochetkov and M K Kukhanova and Yu S Skoblov},
title = {Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs},
journal = {Molecular Biology},
year = {2010},
volume = {44},
publisher = {Pleiades Publishing},
month = {jun},
url = {https://doi.org/10.1134/S0026893310030118},
number = {3},
pages = {431--438},
doi = {10.1134/S0026893310030118}
}
Cite this
MLA
Copy
Korovina, A. N., et al. “Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs.” Molecular Biology, vol. 44, no. 3, Jun. 2010, pp. 431-438. https://doi.org/10.1134/S0026893310030118.
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