Cell defense systems against oxidative stress and endoplasmic reticulum stress: Mechanisms of regulation and the effect of hepatitis C virus
Publication type: Journal Article
Publication date: 2011-02-22
scimago Q3
wos Q4
SJR: 0.331
CiteScore: 1.6
Impact factor: 1.2
ISSN: 00268933, 16083245, 21689547
Structural Biology
Biophysics
Abstract
Hepatitis C virus (HCV) is one of the most widespread and dangerous human pathogens. In most cases, hepatitis C develops into chronic conditions, which often escape antiviral therapy and cause damage to various organs and systems. The conditions include liver fibrosis, steatosis, and hepatocellular carcinoma. These diseases are currently linked to oxidative stress and endoplasmic reticulum (ER) stress, which are induced by virus proteins. At the same time, HCV disturbs the systems that protect cells from these stresses, thus avoiding their effect on the virus life cycle. The review analyzes recent data on the function of the cell defense system in HCV-infected and uninfected cells. In addition, the structure of the HCV genome and the main functions of virus proteins are summarized in brief.
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Smirnova O. A. et al. Cell defense systems against oxidative stress and endoplasmic reticulum stress: Mechanisms of regulation and the effect of hepatitis C virus // Molecular Biology. 2011. Vol. 45. No. 1. pp. 110-122.
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Smirnova O. A., A.V. I., Ivanova O. N., Valuev Elliston V. T., Kochetkov S. N. Cell defense systems against oxidative stress and endoplasmic reticulum stress: Mechanisms of regulation and the effect of hepatitis C virus // Molecular Biology. 2011. Vol. 45. No. 1. pp. 110-122.
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RIS
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TY - JOUR
DO - 10.1134/S0026893311010122
UR - https://doi.org/10.1134/S0026893311010122
TI - Cell defense systems against oxidative stress and endoplasmic reticulum stress: Mechanisms of regulation and the effect of hepatitis C virus
T2 - Molecular Biology
AU - Smirnova, O. A.
AU - A.V., Ivanov
AU - Ivanova, O N
AU - Valuev Elliston, V T
AU - Kochetkov, S. N.
PY - 2011
DA - 2011/02/22
PB - Pleiades Publishing
SP - 110-122
IS - 1
VL - 45
SN - 0026-8933
SN - 1608-3245
SN - 2168-9547
ER -
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@article{2011_Smirnova,
author = {O. A. Smirnova and Ivanov A.V. and O N Ivanova and V T Valuev Elliston and S. N. Kochetkov},
title = {Cell defense systems against oxidative stress and endoplasmic reticulum stress: Mechanisms of regulation and the effect of hepatitis C virus},
journal = {Molecular Biology},
year = {2011},
volume = {45},
publisher = {Pleiades Publishing},
month = {feb},
url = {https://doi.org/10.1134/S0026893311010122},
number = {1},
pages = {110--122},
doi = {10.1134/S0026893311010122}
}
Cite this
MLA
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Smirnova, O. A., et al. “Cell defense systems against oxidative stress and endoplasmic reticulum stress: Mechanisms of regulation and the effect of hepatitis C virus.” Molecular Biology, vol. 45, no. 1, Feb. 2011, pp. 110-122. https://doi.org/10.1134/S0026893311010122.