Molecular Biology, volume 48, issue 5, pages 615-623
Ribonucleases as antiviral agents
Publication type: Journal Article
Publication date: 2014-09-01
Journal:
Molecular Biology
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 1.2
ISSN: 00268933, 16083245, 21689547
Structural Biology
Biophysics
Abstract
Many ribonucleases (RNases) are able to inhibit the reproduction of viruses in infected cell cultures and laboratory animals, but the molecular mechanisms of their antiviral activity remain unclear. The review discusses the well-known RNases that possess established antiviral effects, including both intracellular RNases (RNase L, MCPIP1 protein, and eosinophil-associated RNases) and exogenous RNases (RNase A, BS-RNase, onconase, binase, and synthetic RNases). Attention is paid to two important, but not always obligatory, aspects of molecules of RNases that have antiviral properties, i.e., catalytic activity and ability to dimerize. The hypothetic scheme of virus elimination by exogenous RNases that reflects possible types of interaction of viruses and RNases with a cell is proposed. The evidence for RNases as classical components of immune defense and thus perspective agents for the development of new antiviral therapeutics is proposed.
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TY - JOUR
DO - 10.1134/s0026893314040050
UR - https://doi.org/10.1134/s0026893314040050
TI - Ribonucleases as antiviral agents
T2 - Molecular Biology
AU - Ilinskaya, O N
AU - Mahmud, R S
PY - 2014
DA - 2014/09/01 00:00:00
PB - Pleiades Publishing
SP - 615-623
IS - 5
VL - 48
SN - 0026-8933
SN - 1608-3245
SN - 2168-9547
ER -
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@article{2014,
author = {O N Ilinskaya and R S Mahmud},
title = {Ribonucleases as antiviral agents},
journal = {Molecular Biology},
year = {2014},
volume = {48},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134/s0026893314040050},
number = {5},
pages = {615--623},
doi = {10.1134/s0026893314040050}
}