Molecular Biology, volume 56, issue 2, pages 229-250

Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases

Publication typeJournal Article
Publication date2022-04-14
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor1.2
ISSN00268933, 16083245
Structural Biology
Biophysics
Abstract
Abstract Methyltransferases (MTases) play an important role in the functioning of living systems, catalyzing the methylation reactions of DNA, RNA, proteins, and small molecules, including endogenous compounds and drugs. Many human diseases are associated with disturbances in the functioning of these enzymes; therefore, the study of MTases is an urgent and important task. Most MTases use the cofactor S ‑adenosyl‑ L ‑methionine (SAM) as a methyl group donor. SAM analogs are widely applicable in the study of MTases: they are used in studies of the catalytic activity of these enzymes, in identification of substrates of new MTases, and for modification of the substrates or substrate linking to MTases. In this review, new synthetic analogs of SAM and the problems that can be solved with their usage are discussed.

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Rudenko A. Yu. et al. Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases // Molecular Biology. 2022. Vol. 56. No. 2. pp. 229-250.
GOST all authors (up to 50) Copy
Rudenko A. Yu., Mariasina S. S., Sergiev P. V., Polshakov V. I. Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases // Molecular Biology. 2022. Vol. 56. No. 2. pp. 229-250.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/S002689332202011X
UR - https://doi.org/10.1134%2FS002689332202011X
TI - Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases
T2 - Molecular Biology
AU - Sergiev, P V
AU - Rudenko, A Yu
AU - Polshakov, V I
AU - Mariasina, S S
PY - 2022
DA - 2022/04/14 00:00:00
PB - Pleiades Publishing
SP - 229-250
IS - 2
VL - 56
PMID - 35440827
SN - 0026-8933
SN - 1608-3245
ER -
BibTex |
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BibTex Copy
@article{2022_Rudenko
author = {P V Sergiev and A Yu Rudenko and V I Polshakov and S S Mariasina},
title = {Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases},
journal = {Molecular Biology},
year = {2022},
volume = {56},
publisher = {Pleiades Publishing},
month = {apr},
url = {https://doi.org/10.1134%2FS002689332202011X},
number = {2},
pages = {229--250},
doi = {10.1134/S002689332202011X}
}
MLA
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MLA Copy
Rudenko, A. Yu., et al. “Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases.” Molecular Biology, vol. 56, no. 2, Apr. 2022, pp. 229-250. https://doi.org/10.1134%2FS002689332202011X.
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