Molecular Biology, volume 56, issue 2, pages 229-250
Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases
Publication type: Journal Article
Publication date: 2022-04-14
Journal:
Molecular Biology
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 1.2
ISSN: 00268933, 16083245
PubMed ID:
35440827
Structural Biology
Biophysics
Abstract
Abstract Methyltransferases (MTases) play an important role in the functioning of living systems, catalyzing the methylation reactions of DNA, RNA, proteins, and small molecules, including endogenous compounds and drugs. Many human diseases are associated with disturbances in the functioning of these enzymes; therefore, the study of MTases is an urgent and important task. Most MTases use the cofactor S ‑adenosyl‑ L ‑methionine (SAM) as a methyl group donor. SAM analogs are widely applicable in the study of MTases: they are used in studies of the catalytic activity of these enzymes, in identification of substrates of new MTases, and for modification of the substrates or substrate linking to MTases. In this review, new synthetic analogs of SAM and the problems that can be solved with their usage are discussed.
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Rudenko A. Yu. et al. Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases // Molecular Biology. 2022. Vol. 56. No. 2. pp. 229-250.
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Rudenko A. Yu., Mariasina S. S., Sergiev P. V., Polshakov V. I. Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases // Molecular Biology. 2022. Vol. 56. No. 2. pp. 229-250.
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TY - JOUR
DO - 10.1134/S002689332202011X
UR - https://doi.org/10.1134%2FS002689332202011X
TI - Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases
T2 - Molecular Biology
AU - Sergiev, P V
AU - Rudenko, A Yu
AU - Polshakov, V I
AU - Mariasina, S S
PY - 2022
DA - 2022/04/14 00:00:00
PB - Pleiades Publishing
SP - 229-250
IS - 2
VL - 56
PMID - 35440827
SN - 0026-8933
SN - 1608-3245
ER -
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@article{2022_Rudenko
author = {P V Sergiev and A Yu Rudenko and V I Polshakov and S S Mariasina},
title = {Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases},
journal = {Molecular Biology},
year = {2022},
volume = {56},
publisher = {Pleiades Publishing},
month = {apr},
url = {https://doi.org/10.1134%2FS002689332202011X},
number = {2},
pages = {229--250},
doi = {10.1134/S002689332202011X}
}
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MLA
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Rudenko, A. Yu., et al. “Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases.” Molecular Biology, vol. 56, no. 2, Apr. 2022, pp. 229-250. https://doi.org/10.1134%2FS002689332202011X.