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volume 56 issue 3 pages 469-473

New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2

Publication typeJournal Article
Publication date2022-06-03
scimago Q3
wos Q4
SJR0.331
CiteScore1.6
Impact factor1.2
ISSN00268933, 16083245, 21689547
Structural Biology
Biophysics
Abstract
The development of specific drugs against SARS-CoV-2 infection is a major challenge facing global science and healthcare. Despite numerous attempts, there are still no truly effective drugs. Currently, the main approach in the creation of drugs against COVID-19 is repurposing, i.e., re-profiling existing drugs approved for medical use, for example, the use of a drug for the treatment of Ebola—Remdesivir, and the use of a drug for the treatment of influenza—Favipiravir. However, it is already obvious that these drugs are not specific enough nor effective enough. Another promising approach is the creation of new molecules, but it should be noted immediately that implementation requires much more time and costs. However, the search for new SARS-CoV-2 specific antiviral agents continues. The aim of our work was the creation of new 5-substituted uridine derivatives as potential inhibitors of coronavirus RNA-dependent RNA polymerase. The substances were obtained in high yields by the Suzuki‒Miyaura reaction and characterized using modern physicochemical methods. However, testing of their antiviral activity against SARS-CoV-2 did not reveal a significant inhibitory effect.
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Maslova A. A. et al. New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2 // Molecular Biology. 2022. Vol. 56. No. 3. pp. 469-473.
GOST all authors (up to 50) Copy
Maslova A. A., Matyugina E. C., Shustova E. Yu., Volok V. P., Kozlovskaya L. I., Kochetkov S. N., Khandazhinskaya A. L. New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2 // Molecular Biology. 2022. Vol. 56. No. 3. pp. 469-473.
RIS |
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TY - JOUR
DO - 10.1134/S0026893322030098
UR - https://doi.org/10.1134/S0026893322030098
TI - New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2
T2 - Molecular Biology
AU - Maslova, A A
AU - Matyugina, E C
AU - Shustova, E Yu
AU - Volok, V P
AU - Kozlovskaya, L I
AU - Kochetkov, S. N.
AU - Khandazhinskaya, A L
PY - 2022
DA - 2022/06/03
PB - Pleiades Publishing
SP - 469-473
IS - 3
VL - 56
PMID - 35693979
SN - 0026-8933
SN - 1608-3245
SN - 2168-9547
ER -
BibTex |
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@article{2022_Maslova,
author = {A A Maslova and E C Matyugina and E Yu Shustova and V P Volok and L I Kozlovskaya and S. N. Kochetkov and A L Khandazhinskaya},
title = {New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2},
journal = {Molecular Biology},
year = {2022},
volume = {56},
publisher = {Pleiades Publishing},
month = {jun},
url = {https://doi.org/10.1134/S0026893322030098},
number = {3},
pages = {469--473},
doi = {10.1134/S0026893322030098}
}
MLA
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Maslova, A. A., et al. “New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2.” Molecular Biology, vol. 56, no. 3, Jun. 2022, pp. 469-473. https://doi.org/10.1134/S0026893322030098.