Optics and Spectroscopy (English translation of Optika i Spektroskopiya), volume 129, issue 7, pages 813-820

Spectroscopic Study of the Release Kinetics of Water-Insoluble Drug Griseofulvin from Vaterite Containers in Aqueous Medium

Publication typeJournal Article
Publication date2021-07-01
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor0.6
ISSN0030400X, 15626911
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Abstract
The bioavailability improvement of hydrophobic drugs is one of the major problems in pharmaceutical research as required for the enhancement of their therapeutic efficacy. Encapsulation of such drugs into various micro- and nanocarriers enabling the targeted delivery represents an important strategy here. The process of the designed nanoformulation study generally includes characterization of the payload release profile in model water-based media, which provides a challenge to encapsulated hydrophobic drugs due to their poor solubility in water. Thus, modification of the existed release investigation protocols is required for reliable detection of the liberated hydrophobic drug. Here, we report an optimized multimodal spectroscopic and microscopic study of the release behaviour of griseofulvin (Gf), a water-insoluble antifungal drug, from vaterite carriers. The addition of N,N-dimethylformamide (DMF), a polar aprotic solvent, to aqueous suspensions of Gf-loaded vaterite carriers at the investigated time points right before the UV–Vis spectroscopic measurement allowed us to enhance the accuracy of the released Gf determination. Monitoring of the carrier degradation process by a combination of scanning electron microscopy and Raman spectroscopy demonstrated a good correlation between the obtained data and the payload release kinetics.

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Saveleva M. S. et al. Spectroscopic Study of the Release Kinetics of Water-Insoluble Drug Griseofulvin from Vaterite Containers in Aqueous Medium // Optics and Spectroscopy (English translation of Optika i Spektroskopiya). 2021. Vol. 129. No. 7. pp. 813-820.
GOST all authors (up to 50) Copy
Saveleva M. S., Lengert E. V., Abramova A. M., Shtykov S. N., Svenskaya Yu. I. Spectroscopic Study of the Release Kinetics of Water-Insoluble Drug Griseofulvin from Vaterite Containers in Aqueous Medium // Optics and Spectroscopy (English translation of Optika i Spektroskopiya). 2021. Vol. 129. No. 7. pp. 813-820.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/S0030400X21060126
UR - https://doi.org/10.1134%2FS0030400X21060126
TI - Spectroscopic Study of the Release Kinetics of Water-Insoluble Drug Griseofulvin from Vaterite Containers in Aqueous Medium
T2 - Optics and Spectroscopy (English translation of Optika i Spektroskopiya)
AU - Saveleva, M S
AU - Lengert, E V
AU - Abramova, A M
AU - Shtykov, S N
AU - Svenskaya, Yu I
PY - 2021
DA - 2021/07/01 00:00:00
PB - Pleiades Publishing
SP - 813-820
IS - 7
VL - 129
SN - 0030-400X
SN - 1562-6911
ER -
BibTex |
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@article{2021_Saveleva
author = {M S Saveleva and E V Lengert and A M Abramova and S N Shtykov and Yu I Svenskaya},
title = {Spectroscopic Study of the Release Kinetics of Water-Insoluble Drug Griseofulvin from Vaterite Containers in Aqueous Medium},
journal = {Optics and Spectroscopy (English translation of Optika i Spektroskopiya)},
year = {2021},
volume = {129},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134%2FS0030400X21060126},
number = {7},
pages = {813--820},
doi = {10.1134/S0030400X21060126}
}
MLA
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Saveleva, M. S., et al. “Spectroscopic Study of the Release Kinetics of Water-Insoluble Drug Griseofulvin from Vaterite Containers in Aqueous Medium.” Optics and Spectroscopy (English translation of Optika i Spektroskopiya), vol. 129, no. 7, Jul. 2021, pp. 813-820. https://doi.org/10.1134%2FS0030400X21060126.
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