Derivatives of closo-Decaborate Anion with Polyamines

The reactions of 1,4-dioxane derivative of closo-decaborate anion with hydrazine and a number of polyamines (tetraethylenepentamine, triethylenetetramine, tris(2-aminoethyl)amine, bis(3-aminopropyl)amine, and N,N'-bis(3-aminopropyl)-1,4-diaminobutane) in ethanol were studied. It was shown that in these reactions in which polyamines act as nucleophiles, the substituent ring is opened with addition of the corresponding pendant functional group. The obtained derivatives of the closo-decaborate anion with polyamine moieties linked to the boron cluster via an alkoxyl spacer are promising for preparing new substances with potential pharmacological activity for the use in boron neutron capture therapy of malignant tumors. The introduced polyamine groups allow the obtained closo-borates to bind to various polyanionic targets in the cell (DNA, RNA, phospholipids, charged protein sites, etc.). The products were studied by various physicochemical methods (IR and heteronuclear NMR spectroscopy, ESI MS spectrometry).