Human Physiology, volume 47, issue 6, pages 619-627

A Multiparametric Approach to the Assessment of Cutaneous Microcirculation in Dermatological Patients (on the Example of Patients with Psoriasis)

Potapova E V ¹

Mikhailova M A ^{1, 2}

Koroleva A K ¹

Stavtsev D D ¹

Dremin V V ^{1, 3}

Dunaev A.V. ¹

Yakushkina N Yu ^{1, 4}

Krupatkin A I ⁵

Margaryants N B ⁶

Hide authors affiliations Show authors affiliations: 6 affiliations

Orel State University, Orel, Russia |

National Medical Research Center for Therapy and Preventive Medicine, Ministry of Health of the Russian Federation, Moscow, Russia |

Aston University, Birmingham, United Kingdom |

⁴

Orel Regional Dermatovenerological Dispensary, Orel, Russia |

⁵

Priorov National Medical Research Center for Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Moscow, Russia |

⁶

National Research University ITMO, St. Petersburg, Russia |

Publication type: Journal Article

Publication date: 2021-11-01

Pleiades Publishing

Journal: Human Physiology

Quartile SCImago

Quartile WOS

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Impact factor: —

ISSN: 03621197, 16083164

DOI: 10.1134/S0362119721050091

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Physiology

Physiology (medical)

Abstract

The article describes a multiparametric approach to the assessment of cutaneous microcirculation in dermatological patients (using the example of psoriasis patients). The multiparametric diagnostic approach consisted of three stages of successive measurements performed according to the methodology of laser speckle contrast imaging (LSCI), laser Doppler flowmetry (LDF), and videocapillaroscopy (VCS). Experimental studies on hemodynamic parameters were conducted in psoriatic patients with a course of conservative treatment. A combined application of optical noninvasive diagnostic methods allowed physicians to record changes taking place in the microcirculatory bed during treatment. It has been found that microcirculatory disorders observed before the start of treatment in the field of psoriatic plaques (an increase in the density of the capillary network, an increase in the indicator of microcirculation, nutritive blood flow and the amplitudes of myogenic and cardiac oscillations) were normalized due to the applied treatment, on which the assessment of its efficacy may be based. The suggested approach may be used for diagnosing microcirculatory disorders emerging in psoriasis in its preclinical stage, as well as for developing and testing new pharmacological means for its treatment.

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Potapova E. V. et al. A Multiparametric Approach to the Assessment of Cutaneous Microcirculation in Dermatological Patients (on the Example of Patients with Psoriasis) // Human Physiology. 2021. Vol. 47. No. 6. pp. 619-627.

GOST all authors (up to 50) Copy

Potapova E. V., Mikhailova M. A., Koroleva A. K., Stavtsev D. D., Dremin V. V., Dunaev A., Yakushkina N. Yu., Krupatkin A. I., Margaryants N. B. A Multiparametric Approach to the Assessment of Cutaneous Microcirculation in Dermatological Patients (on the Example of Patients with Psoriasis) // Human Physiology. 2021. Vol. 47. No. 6. pp. 619-627.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1134/S0362119721050091

UR - https://doi.org/10.1134%2FS0362119721050091

TI - A Multiparametric Approach to the Assessment of Cutaneous Microcirculation in Dermatological Patients (on the Example of Patients with Psoriasis)

T2 - Human Physiology

AU - Potapova, E V

AU - Mikhailova, M A

AU - Koroleva, A K

AU - Dremin, V V

AU - Dunaev, A.V.

AU - Yakushkina, N Yu

AU - Margaryants, N B

AU - Stavtsev, D D

AU - Krupatkin, A I

PY - 2021

DA - 2021/11/01 00:00:00

PB - Pleiades Publishing

SP - 619-627

IS - 6

VL - 47

SN - 0362-1197

SN - 1608-3164

ER -

BibTex |

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BibTex Copy

@article{2021_Potapova,

author = {E V Potapova and M A Mikhailova and A K Koroleva and V V Dremin and A.V. Dunaev and N Yu Yakushkina and N B Margaryants and D D Stavtsev and A I Krupatkin},

title = {A Multiparametric Approach to the Assessment of Cutaneous Microcirculation in Dermatological Patients (on the Example of Patients with Psoriasis)},

journal = {Human Physiology},

year = {2021},

volume = {47},

publisher = {Pleiades Publishing},

month = {nov},

url = {https://doi.org/10.1134%2FS0362119721050091},

number = {6},

pages = {619--627},

doi = {10.1134/S0362119721050091}

}

MLA

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MLA Copy

Potapova, E. V., et al. “A Multiparametric Approach to the Assessment of Cutaneous Microcirculation in Dermatological Patients (on the Example of Patients with Psoriasis).” Human Physiology, vol. 47, no. 6, Nov. 2021, pp. 619-627. https://doi.org/10.1134%2FS0362119721050091.

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Publisher

Pleiades Publishing

Journal

Human Physiology

Quartile SCImago

Quartile WOS

—

Impact factor

—

ISSN

03621197 (Print)
16083164 (Electronic)

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Scientific and Technological Center of Biomedical Photonics

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