Free-radical cross-linking of serum albumin molecules on the surface of magnetite nanoparticles in aqueous dispersion
A.V. Bychkova
1
,
M. A. Rosenfeld
1
,
V B Leonova
1
,
O N Sorokina
1
,
S. M. Lomakin
1
,
A L Kovarski
1
Publication type: Journal Article
Publication date: 2013-01-31
scimago Q4
wos Q4
SJR: 0.220
CiteScore: 2.3
Impact factor: 1.1
ISSN: 1061933X, 16083067
Physical and Theoretical Chemistry
Colloid and Surface Chemistry
Surfaces and Interfaces
Abstract
A novel universal approach to cross-linking of protein macromolecules on the surface of magnetite nanoparticles has been developed. The approach is based on protein liability to free-radical modification, leading to the formation of intermolecular covalent cross-links. Free radicals are locally generated on the surface of nanoparticles. Stable coatings of serum albumin 3 nm thick are formed on the surface of magnetite nanoparticles. Using a set of physicochemical methods, it has been proven that stable coatings composed of protein macromolecules are formed around individual nanoparticles. The presence of reactive groups in the protein structure makes it possible to perform subsequent modification of the surface layers-in particular, to graft nonprotein drugs. The approach developed can be used to create superfine systems with desired surface properties for targeted delivery of drugs and biologically active substances.
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15
Total citations:
15
Citations from 2024:
3
(20%)
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MLA
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GOST
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Bychkova A. et al. Free-radical cross-linking of serum albumin molecules on the surface of magnetite nanoparticles in aqueous dispersion // Colloid Journal. 2013. Vol. 75. No. 1. pp. 7-13.
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Bychkova A., Rosenfeld M. A., Leonova V. B., Sorokina O. N., Lomakin S. M., Kovarski A. L. Free-radical cross-linking of serum albumin molecules on the surface of magnetite nanoparticles in aqueous dispersion // Colloid Journal. 2013. Vol. 75. No. 1. pp. 7-13.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/S1061933X13010031
UR - https://doi.org/10.1134/S1061933X13010031
TI - Free-radical cross-linking of serum albumin molecules on the surface of magnetite nanoparticles in aqueous dispersion
T2 - Colloid Journal
AU - Bychkova, A.V.
AU - Rosenfeld, M. A.
AU - Leonova, V B
AU - Sorokina, O N
AU - Lomakin, S. M.
AU - Kovarski, A L
PY - 2013
DA - 2013/01/31
PB - Pleiades Publishing
SP - 7-13
IS - 1
VL - 75
SN - 1061-933X
SN - 1608-3067
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2013_Bychkova,
author = {A.V. Bychkova and M. A. Rosenfeld and V B Leonova and O N Sorokina and S. M. Lomakin and A L Kovarski},
title = {Free-radical cross-linking of serum albumin molecules on the surface of magnetite nanoparticles in aqueous dispersion},
journal = {Colloid Journal},
year = {2013},
volume = {75},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134/S1061933X13010031},
number = {1},
pages = {7--13},
doi = {10.1134/S1061933X13010031}
}
Cite this
MLA
Copy
Bychkova, A.V., et al. “Free-radical cross-linking of serum albumin molecules on the surface of magnetite nanoparticles in aqueous dispersion.” Colloid Journal, vol. 75, no. 1, Jan. 2013, pp. 7-13. https://doi.org/10.1134/S1061933X13010031.
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