A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin
Publication type: Journal Article
Publication date: 2017-09-19
scimago Q4
wos Q4
SJR: 0.220
CiteScore: 2.3
Impact factor: 1.1
ISSN: 1061933X, 16083067
Physical and Theoretical Chemistry
Colloid and Surface Chemistry
Surfaces and Interfaces
Abstract
The physicochemical properties and structure of moxifloxacin‒methyl-β-cyclodextrin complex have been studied by UV spectroscopy, FTIR spectroscopy, and computer simulation. The optimal conditions for the formation of the complex have been determined, and the dissociation constant of the complex in acidic media (K dis = (5.0 ± 0.3) × 10–5 М) has been obtained. It has been found that complexation significantly slows down the release of the drug in acidic media. Experimental results are in good agreement with computer simulation data. The following mechanism of complex formation has been proposed: the incorporation of the aromatic fragment of moxifloxacin into the cavity of methyl-β-cyclodextrin is followed by additional stabilization of the complex via multiple hydrophobic interactions and hydrogen bonding.
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Total citations:
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Citations from 2025:
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(6.67%)
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GOST
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Skuredina A. A. et al. A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin // Colloid Journal. 2017. Vol. 79. No. 5. pp. 668-676.
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Skuredina A. A., Le Deygen I. M., Uporov I., Kudryashova E. V. A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin // Colloid Journal. 2017. Vol. 79. No. 5. pp. 668-676.
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RIS
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TY - JOUR
DO - 10.1134/S1061933X17050143
UR - http://link.springer.com/10.1134/S1061933X17050143
TI - A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin
T2 - Colloid Journal
AU - Skuredina, A A
AU - Le Deygen, I M
AU - Uporov, I.V.
AU - Kudryashova, E V
PY - 2017
DA - 2017/09/19
PB - Pleiades Publishing
SP - 668-676
IS - 5
VL - 79
SN - 1061-933X
SN - 1608-3067
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Skuredina,
author = {A A Skuredina and I M Le Deygen and I.V. Uporov and E V Kudryashova},
title = {A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin},
journal = {Colloid Journal},
year = {2017},
volume = {79},
publisher = {Pleiades Publishing},
month = {sep},
url = {http://link.springer.com/10.1134/S1061933X17050143},
number = {5},
pages = {668--676},
doi = {10.1134/S1061933X17050143}
}
Cite this
MLA
Copy
Skuredina, A. A., et al. “A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin.” Colloid Journal, vol. 79, no. 5, Sep. 2017, pp. 668-676. http://link.springer.com/10.1134/S1061933X17050143.