A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin
Тип публикации: Journal Article
Дата публикации: 2017-09-19
scimago Q4
wos Q4
БС2
SJR: 0.220
CiteScore: 2.3
Impact factor: 1.1
ISSN: 1061933X, 16083067
Physical and Theoretical Chemistry
Colloid and Surface Chemistry
Surfaces and Interfaces
Краткое описание
The physicochemical properties and structure of moxifloxacin‒methyl-β-cyclodextrin complex have been studied by UV spectroscopy, FTIR spectroscopy, and computer simulation. The optimal conditions for the formation of the complex have been determined, and the dissociation constant of the complex in acidic media (K dis = (5.0 ± 0.3) × 10–5 М) has been obtained. It has been found that complexation significantly slows down the release of the drug in acidic media. Experimental results are in good agreement with computer simulation data. The following mechanism of complex formation has been proposed: the incorporation of the aromatic fragment of moxifloxacin into the cavity of methyl-β-cyclodextrin is followed by additional stabilization of the complex via multiple hydrophobic interactions and hydrogen bonding.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Топ-30
Журналы
|
1
2
|
|
|
Moscow University Chemistry Bulletin
2 публикации, 13.33%
|
|
|
Pharmaceuticals
2 публикации, 13.33%
|
|
|
Russian Journal of Physical Chemistry B
1 публикация, 6.67%
|
|
|
Colloid Journal
1 публикация, 6.67%
|
|
|
Russian Journal of Bioorganic Chemistry
1 публикация, 6.67%
|
|
|
Pharmaceutics
1 публикация, 6.67%
|
|
|
Journal of Molecular Liquids
1 публикация, 6.67%
|
|
|
Russian Chemical Reviews
1 публикация, 6.67%
|
|
|
Journal of Electroanalytical Chemistry
1 публикация, 6.67%
|
|
|
Biotekhnologiya
1 публикация, 6.67%
|
|
|
Journal of Structural Chemistry
1 публикация, 6.67%
|
|
|
Science of the Total Environment
1 публикация, 6.67%
|
|
|
International Journal of Biological Macromolecules
1 публикация, 6.67%
|
|
|
1
2
|
Издатели
|
1
2
3
4
5
6
|
|
|
Pleiades Publishing
6 публикаций, 40%
|
|
|
Elsevier
4 публикации, 26.67%
|
|
|
MDPI
3 публикации, 20%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 публикация, 6.67%
|
|
|
State Research Institute for Genetics and Selection of Industrial Microorganisms
1 публикация, 6.67%
|
|
|
1
2
3
4
5
6
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
15
Всего цитирований:
15
Цитирований c 2024:
2
(13.34%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Skuredina A. A. et al. A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin // Colloid Journal. 2017. Vol. 79. No. 5. pp. 668-676.
ГОСТ со всеми авторами (до 50)
Скопировать
Skuredina A. A., Le Deygen I. M., Uporov I., Kudryashova E. V. A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin // Colloid Journal. 2017. Vol. 79. No. 5. pp. 668-676.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1134/S1061933X17050143
UR - http://link.springer.com/10.1134/S1061933X17050143
TI - A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin
T2 - Colloid Journal
AU - Skuredina, A A
AU - Le Deygen, I M
AU - Uporov, I.V.
AU - Kudryashova, E V
PY - 2017
DA - 2017/09/19
PB - Pleiades Publishing
SP - 668-676
IS - 5
VL - 79
SN - 1061-933X
SN - 1608-3067
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2017_Skuredina,
author = {A A Skuredina and I M Le Deygen and I.V. Uporov and E V Kudryashova},
title = {A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin},
journal = {Colloid Journal},
year = {2017},
volume = {79},
publisher = {Pleiades Publishing},
month = {sep},
url = {http://link.springer.com/10.1134/S1061933X17050143},
number = {5},
pages = {668--676},
doi = {10.1134/S1061933X17050143}
}
Цитировать
MLA
Скопировать
Skuredina, A. A., et al. “A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin.” Colloid Journal, vol. 79, no. 5, Sep. 2017, pp. 668-676. http://link.springer.com/10.1134/S1061933X17050143.