Colloid Journal

, volume 80 , issue 3 , pages 312-319

The Effect of Molecular Architecture of Sulfobutyl Ether β-Cyclodextrin Nanoparticles on Physicochemical Properties of Complexes with Moxifloxacin

A A Skuredina ¹

I M Le Deygen ¹

E V Kudryashova ¹

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Department of Chemistry, Moscow State University, Moscow, Russia |

Publication type: Journal Article

Publication date: 2018-05-01

Pleiades Publishing

Colloid Journal

scimago Q4

wos Q4

SJR: 0.220

CiteScore: 2.3

Impact factor: 1.1

ISSN: 1061933X, 16083067

DOI: 10.1134/S1061933X18030134

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Physical and Theoretical Chemistry

Colloid and Surface Chemistry

Surfaces and Interfaces

Abstract

A method has been developed for nanoparticles synthesis based on oligomers of sulfobutyl ether β-cyclodextrin (SBE-β-CD) and their structure has been studied by FTIR spectroscopy. The physicochemical properties of “guest−host” inclusion complexes formed by SBE-β-CD and its oligomers with moxifloxacin have been investigated. It has been shown that, as compared with SBE-β-CD, the synthesized oligomers have an increased affinity for moxifloxacin: the dissociation constants for the complexes of monomeric and oligomeric SBE-β-CD are (1.0 ± 0.3) × 10−4 and nearly 5 × 10−6 M, respectively. The binding efficiency increases due to the multy-point interaction of a moxifloxacin molecule with functional groups of the oligomeric carrier. SBE-β-CD oligomers are promising carriers for drugs, in particular, fluoroquinolone-based antibacterial agents, and may be used for the development of new compositions with improved solubility, bioavailability, and prolonged drug release.

Found

6 citations

Le-Deygen Irina

🥼 🤝

PhD in Chemistry

68 publications, 2 751 citations, 8 reviews

h-index: 19

Lomonosov Moscow State University

Research interests

Antibiotics

Chitosan

Drug delivery systems

Polymers for drug delivery

Proteins

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Skuredina A. A., Le Deygen I. M., Kudryashova E. V. The Effect of Molecular Architecture of Sulfobutyl Ether β-Cyclodextrin Nanoparticles on Physicochemical Properties of Complexes with Moxifloxacin // Colloid Journal. 2018. Vol. 80. No. 3. pp. 312-319.

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RIS |

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RIS Copy

TY - JOUR

DO - 10.1134/S1061933X18030134

UR - https://doi.org/10.1134/S1061933X18030134

TI - The Effect of Molecular Architecture of Sulfobutyl Ether β-Cyclodextrin Nanoparticles on Physicochemical Properties of Complexes with Moxifloxacin

T2 - Colloid Journal

AU - Skuredina, A A

AU - Le Deygen, I M

AU - Kudryashova, E V

PY - 2018

DA - 2018/05/01

PB - Pleiades Publishing

SP - 312-319

IS - 3

VL - 80

SN - 1061-933X

SN - 1608-3067

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2018_Skuredina,

author = {A A Skuredina and I M Le Deygen and E V Kudryashova},

title = {The Effect of Molecular Architecture of Sulfobutyl Ether β-Cyclodextrin Nanoparticles on Physicochemical Properties of Complexes with Moxifloxacin},

journal = {Colloid Journal},

year = {2018},

volume = {80},

publisher = {Pleiades Publishing},

month = {may},

url = {https://doi.org/10.1134/S1061933X18030134},

number = {3},

pages = {312--319},

doi = {10.1134/S1061933X18030134}

}

MLA

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MLA Copy

Skuredina, A. A., et al. “The Effect of Molecular Architecture of Sulfobutyl Ether β-Cyclodextrin Nanoparticles on Physicochemical Properties of Complexes with Moxifloxacin.” Colloid Journal, vol. 80, no. 3, May. 2018, pp. 312-319. https://doi.org/10.1134/S1061933X18030134.

Publisher

Pleiades Publishing

Journal

Colloid Journal

scimago Q4

wos Q4

SJR

0.220

CiteScore

2.3

Impact factor

1.1

ISSN

1061933X (Print)

16083067 (Electronic)

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