A simple and easy approach to the derivatization of alcohols for study by soft ionization mass spectrometry methods
Publication type: Journal Article
Publication date: 2015-12-15
scimago Q3
wos Q4
SJR: 0.252
CiteScore: 1.9
Impact factor: 1.1
ISSN: 10619348, 16083199
Analytical Chemistry
Abstract
A simple and convenient method for the derivatization of alcohols for their subsequent analysis by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has been proposed. The method includes the acylation of alcohols by bromoacetyl chloride followed by treatment with a base (triethylamine in this work). If amine is used as a base, an excessive amount of it in the reaction mixture immediately reacts with bromoacetate and the process in fact consists of one stage. MALDI mass spectra of the formed quaternary salts recorded in the presence of non-acid matrices or using a target with a nanostructured surface demonstrated only peaks for cationic parts of the derivatives. Using a mixture of aliphatic primary alcohols from C2 to C18, it has been shown that the derivatization reaction proceeds completely and MALDI mass spectra can be used not only for the determination of their molecular masses, but also for their quantitative analysis and profiling.
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Borisov R. S. et al. A simple and easy approach to the derivatization of alcohols for study by soft ionization mass spectrometry methods // Journal of Analytical Chemistry. 2015. Vol. 70. No. 13. pp. 1542-1545.
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Borisov R. S., Polovkov N. Yu., Zhilyaev D. I., Zaikin V. G. A simple and easy approach to the derivatization of alcohols for study by soft ionization mass spectrometry methods // Journal of Analytical Chemistry. 2015. Vol. 70. No. 13. pp. 1542-1545.
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TY - JOUR
DO - 10.1134/S106193481513002X
UR - https://doi.org/10.1134/S106193481513002X
TI - A simple and easy approach to the derivatization of alcohols for study by soft ionization mass spectrometry methods
T2 - Journal of Analytical Chemistry
AU - Borisov, R S
AU - Polovkov, N Yu
AU - Zhilyaev, D I
AU - Zaikin, V G
PY - 2015
DA - 2015/12/15
PB - Pleiades Publishing
SP - 1542-1545
IS - 13
VL - 70
SN - 1061-9348
SN - 1608-3199
ER -
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@article{2015_Borisov,
author = {R S Borisov and N Yu Polovkov and D I Zhilyaev and V G Zaikin},
title = {A simple and easy approach to the derivatization of alcohols for study by soft ionization mass spectrometry methods},
journal = {Journal of Analytical Chemistry},
year = {2015},
volume = {70},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://doi.org/10.1134/S106193481513002X},
number = {13},
pages = {1542--1545},
doi = {10.1134/S106193481513002X}
}
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Borisov, R. S., et al. “A simple and easy approach to the derivatization of alcohols for study by soft ionization mass spectrometry methods.” Journal of Analytical Chemistry, vol. 70, no. 13, Dec. 2015, pp. 1542-1545. https://doi.org/10.1134/S106193481513002X.
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