Journal of Analytical Chemistry, volume 77, issue 4, pages 439-449
Prospects for Using Chromatography–Mass Spectrometry for the Determination of Lipids in Clinical Cardiolipidology
Alessenko A.V.
1
,
Shupik M A
1
,
Gutner U A
1
,
Zateyshchikov D A
2
,
Minushkina L O
2
,
Rogozhina A A
2
,
Lebedev A. T.
3
,
Maloshitskaya O A
1, 3
,
Sokolov S. A.
3
,
Kurochkin I N
1, 3
Publication type: Journal Article
Publication date: 2022-04-12
Journal:
Journal of Analytical Chemistry
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 1.1
ISSN: 10619348, 16083199
Analytical Chemistry
Abstract
Cardiolipidology – a new direction in cardiology – is developing intensively owing to the method of mass spectrometry. This method has acquired particular importance for the determination of molecular types of sphingolipids, the metabolism of which is closely related to the metabolism of cholesterol. Changes in the level of a number of sphingolipids claiming to be markers of cardiovascular diseases (CVDs) (molecular forms of sphingomyelins, ceramides, glucosylceramides, sphingosine, and sphinganin), in the blood plasma of patients with hereditary forms of early atherosclerosis (familial hyperlipidemia, FHL) were studied by chromatography–mass spectrometry. The study group (52 people) consisted of patients with acute manifestations of atherosclerosis, with postinfarction cardiosclerosis, and with dyslipidemia or early CVD. In patients with FHL, there was an increase in the proportion of long-chain sphingomyelin SM18:1/22:0 and the level of ceramides with carbon chains C20-1 and C22-1. An increase in the level of sphingosine, possessing proapoptotic properties, which can be considered as a marker of an additional risk of cardiovascular complications, was revealed in patients with a high clinical probability of FHL. The search for new CVD markers will improve personalized approach to the management of such patients and improve the results of their treatment.
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Alessenko A. et al. Prospects for Using Chromatography–Mass Spectrometry for the Determination of Lipids in Clinical Cardiolipidology // Journal of Analytical Chemistry. 2022. Vol. 77. No. 4. pp. 439-449.
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Alessenko A., Shupik M. A., Gutner U. A., Zateyshchikov D. A., Minushkina L. O., Rogozhina A. A., Lebedev A. T., Maloshitskaya O. A., Sokolov S. A., Kurochkin I. N. Prospects for Using Chromatography–Mass Spectrometry for the Determination of Lipids in Clinical Cardiolipidology // Journal of Analytical Chemistry. 2022. Vol. 77. No. 4. pp. 439-449.
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TY - JOUR
DO - 10.1134/S1061934822040025
UR - https://doi.org/10.1134%2FS1061934822040025
TI - Prospects for Using Chromatography–Mass Spectrometry for the Determination of Lipids in Clinical Cardiolipidology
T2 - Journal of Analytical Chemistry
AU - Alessenko, A.V.
AU - Shupik, M A
AU - Gutner, U A
AU - Zateyshchikov, D A
AU - Minushkina, L O
AU - Rogozhina, A A
AU - Lebedev, A. T.
AU - Maloshitskaya, O A
AU - Sokolov, S. A.
AU - Kurochkin, I N
PY - 2022
DA - 2022/04/12 00:00:00
PB - Pleiades Publishing
SP - 439-449
IS - 4
VL - 77
SN - 1061-9348
SN - 1608-3199
ER -
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@article{2022_Alessenko,
author = {A.V. Alessenko and M A Shupik and U A Gutner and D A Zateyshchikov and L O Minushkina and A A Rogozhina and A. T. Lebedev and O A Maloshitskaya and S. A. Sokolov and I N Kurochkin},
title = {Prospects for Using Chromatography–Mass Spectrometry for the Determination of Lipids in Clinical Cardiolipidology},
journal = {Journal of Analytical Chemistry},
year = {2022},
volume = {77},
publisher = {Pleiades Publishing},
month = {apr},
url = {https://doi.org/10.1134%2FS1061934822040025},
number = {4},
pages = {439--449},
doi = {10.1134/S1061934822040025}
}
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Alessenko, A.V., et al. “Prospects for Using Chromatography–Mass Spectrometry for the Determination of Lipids in Clinical Cardiolipidology.” Journal of Analytical Chemistry, vol. 77, no. 4, Apr. 2022, pp. 439-449. https://doi.org/10.1134%2FS1061934822040025.
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