Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS
A O Melekhin
1, 2
,
V.V. Tolmacheva
1
,
Yu N Kholyavskaya
2
,
E S Sedykh
2
,
S G Dmitrienko
1
,
V V Apyari
1
,
A L Bairov
2
2
Central Research and Methodological Veterinary Laboratory, Moscow, Russia
|
Publication type: Journal Article
Publication date: 2022-10-07
scimago Q3
wos Q4
SJR: 0.252
CiteScore: 1.9
Impact factor: 1.1
ISSN: 10619348, 16083199
Analytical Chemistry
Abstract
We proposed a procedure for the rapid sample preparation of food samples for the determination of nitrofuran metabolites in them by HPLC–MS/MS, using 5-nitro-2-furaldehyde as a new derivatizing agent. Meat samples from broiler chickens treated with nitrofurans for 10 days were used to demonstrate that the time of hydrolysis–derivatization in a thermostated ultrasonic bath could be significantly shortened by raising temperature to 80°C and increasing the concentration of hydrochloric acid to 0.5 M. Metabolites of Furaltadone, Furazolidone, Nitrofurantoin, and Nitrofurazone in chicken meat, liver, stomach, and heart are determined using the developed procedure and an official method. The proposed method ensures the quantitative isolation of metabolites.
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Melekhin A. O. et al. Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS // Journal of Analytical Chemistry. 2022. Vol. 77. No. 10. pp. 1300-1306.
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Melekhin A. O., Tolmacheva V., Kholyavskaya Yu. N., Sedykh E. S., Dmitrienko S. G., Apyari V. V., Bairov A. L. Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS // Journal of Analytical Chemistry. 2022. Vol. 77. No. 10. pp. 1300-1306.
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TY - JOUR
DO - 10.1134/S1061934822100112
UR - https://link.springer.com/10.1134/S1061934822100112
TI - Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS
T2 - Journal of Analytical Chemistry
AU - Melekhin, A O
AU - Tolmacheva, V.V.
AU - Kholyavskaya, Yu N
AU - Sedykh, E S
AU - Dmitrienko, S G
AU - Apyari, V V
AU - Bairov, A L
PY - 2022
DA - 2022/10/07
PB - Pleiades Publishing
SP - 1300-1306
IS - 10
VL - 77
SN - 1061-9348
SN - 1608-3199
ER -
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BibTex (up to 50 authors)
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@article{2022_Melekhin,
author = {A O Melekhin and V.V. Tolmacheva and Yu N Kholyavskaya and E S Sedykh and S G Dmitrienko and V V Apyari and A L Bairov},
title = {Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS},
journal = {Journal of Analytical Chemistry},
year = {2022},
volume = {77},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://link.springer.com/10.1134/S1061934822100112},
number = {10},
pages = {1300--1306},
doi = {10.1134/S1061934822100112}
}
Cite this
MLA
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Melekhin, A. O., et al. “Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS.” Journal of Analytical Chemistry, vol. 77, no. 10, Oct. 2022, pp. 1300-1306. https://link.springer.com/10.1134/S1061934822100112.