Crystallography Reports, volume 66, issue 5, pages 846-853

Study of GroEL Conformational Mobility by Cryo-Electron Microscopy and Molecular Dynamics

Publication typeJournal Article
Publication date2021-09-01
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor0.7
ISSN10637745, 1562689X
General Chemistry
Condensed Matter Physics
General Materials Science
Abstract

Bacterial chaperonin GroEL is a complex ring-shaped protein oligomer that promotes the folding of other proteins by encapsulating them in the cavity. There is very little structural information about the disordered C-terminal fragment of the GroEL subunits, which is involved in the folding of the substrate protein. A 3D reconstruction of the GroEL apo-form was obtained by cryo-electron microscopy (cryo-EM) with a resolution of 3.02 Å and supplemented by molecular dynamics (MD) calculations. The results of cryo-EM and MD are in good agreement and demonstrate a diverse mobility of the protein subunit domains. The MD results predict the dynamics and the network of intramolecular contacts of the C-terminal sections of the protein. These results are of great importance for the subsequent study of the mechanism of protein folding in the GroEL cavity.

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Panina I. S. et al. Study of GroEL Conformational Mobility by Cryo-Electron Microscopy and Molecular Dynamics // Crystallography Reports. 2021. Vol. 66. No. 5. pp. 846-853.
GOST all authors (up to 50) Copy
Panina I. S., Mamchur A. A., Yaroshevich I. A., Zlenko D. V., Pichkur E. B., Kudryavtseva S. S., Muronetz V. I., Sokolova O. S., Stanishneva Konovalova T. B. Study of GroEL Conformational Mobility by Cryo-Electron Microscopy and Molecular Dynamics // Crystallography Reports. 2021. Vol. 66. No. 5. pp. 846-853.
RIS |
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TY - JOUR
DO - 10.1134/S1063774521050163
UR - https://doi.org/10.1134%2FS1063774521050163
TI - Study of GroEL Conformational Mobility by Cryo-Electron Microscopy and Molecular Dynamics
T2 - Crystallography Reports
AU - Panina, I S
AU - Mamchur, A A
AU - Yaroshevich, I A
AU - Zlenko, D V
AU - Pichkur, E B
AU - Kudryavtseva, S. S.
AU - Muronetz, V I
AU - Sokolova, O. S.
AU - Stanishneva Konovalova, T B
PY - 2021
DA - 2021/09/01 00:00:00
PB - Pleiades Publishing
SP - 846-853
IS - 5
VL - 66
SN - 1063-7745
SN - 1562-689X
ER -
BibTex |
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@article{2021_Panina
author = {I S Panina and A A Mamchur and I A Yaroshevich and D V Zlenko and E B Pichkur and S. S. Kudryavtseva and V I Muronetz and O. S. Sokolova and T B Stanishneva Konovalova},
title = {Study of GroEL Conformational Mobility by Cryo-Electron Microscopy and Molecular Dynamics},
journal = {Crystallography Reports},
year = {2021},
volume = {66},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134%2FS1063774521050163},
number = {5},
pages = {846--853},
doi = {10.1134/S1063774521050163}
}
MLA
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Panina, I. S., et al. “Study of GroEL Conformational Mobility by Cryo-Electron Microscopy and Molecular Dynamics.” Crystallography Reports, vol. 66, no. 5, Sep. 2021, pp. 846-853. https://doi.org/10.1134%2FS1063774521050163.
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