Thermodynamic Analysis of the Conformational Stability of a Single-Domain Therapeutic Antibody
I E Eliseev
1
,
A N Yudenko
1
,
N. A. Besedina
1
,
A B Ulitin
2
,
V M Ekimova
2
,
S R Evdokimov
2
,
J V Putintceva
2
,
P. A. Yakovlev
2
,
M I Lomovskaya
2
,
I N Terterov
1
,
A. A. Bogdanov
1
,
M V Dubina
3
Publication type: Journal Article
Publication date: 2017-12-01
scimago Q3
wos Q4
SJR: 0.215
CiteScore: 1.1
Impact factor: 0.9
ISSN: 10637850, 10906533, 17267471
Physics and Astronomy (miscellaneous)
Abstract
The stability of a new single-domain therapeutic antibody to the ErbB3 receptor was studied by fluorescence spectroscopy at different concentrations of a denaturing agent and temperatures. The analysis of experimental denaturation curves allowed us to build a complete thermodynamic model of unfolding and to determine all parameters of the transition: ΔG = 8.5 kcal mol–1, Tm = 76°C, ΔHm = 107 kcal mol–1, ΔCp = 1.8 kcal K–1 mol–1. The obtained data evidence the high stability of the antibody in a broad range of conditions, which is essential for further structural and functional studies and possible therapeutic application.
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Eliseev I. E. et al. Thermodynamic Analysis of the Conformational Stability of a Single-Domain Therapeutic Antibody // Technical Physics Letters. 2017. Vol. 43. No. 12. pp. 1088-1091.
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Eliseev I. E., Yudenko A. N., Besedina N. A., Ulitin A. B., Ekimova V. M., Evdokimov S. R., Putintceva J. V., Yakovlev P. A., Lomovskaya M. I., Terterov I. N., Bogdanov A. A., Dubina M. V. Thermodynamic Analysis of the Conformational Stability of a Single-Domain Therapeutic Antibody // Technical Physics Letters. 2017. Vol. 43. No. 12. pp. 1088-1091.
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RIS
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TY - JOUR
DO - 10.1134/S1063785017120045
UR - https://doi.org/10.1134/S1063785017120045
TI - Thermodynamic Analysis of the Conformational Stability of a Single-Domain Therapeutic Antibody
T2 - Technical Physics Letters
AU - Eliseev, I E
AU - Yudenko, A N
AU - Besedina, N. A.
AU - Ulitin, A B
AU - Ekimova, V M
AU - Evdokimov, S R
AU - Putintceva, J V
AU - Yakovlev, P. A.
AU - Lomovskaya, M I
AU - Terterov, I N
AU - Bogdanov, A. A.
AU - Dubina, M V
PY - 2017
DA - 2017/12/01
PB - Pleiades Publishing
SP - 1088-1091
IS - 12
VL - 43
SN - 1063-7850
SN - 1090-6533
SN - 1726-7471
ER -
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BibTex (up to 50 authors)
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@article{2017_Eliseev,
author = {I E Eliseev and A N Yudenko and N. A. Besedina and A B Ulitin and V M Ekimova and S R Evdokimov and J V Putintceva and P. A. Yakovlev and M I Lomovskaya and I N Terterov and A. A. Bogdanov and M V Dubina},
title = {Thermodynamic Analysis of the Conformational Stability of a Single-Domain Therapeutic Antibody},
journal = {Technical Physics Letters},
year = {2017},
volume = {43},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://doi.org/10.1134/S1063785017120045},
number = {12},
pages = {1088--1091},
doi = {10.1134/S1063785017120045}
}
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MLA
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Eliseev, I. E., et al. “Thermodynamic Analysis of the Conformational Stability of a Single-Domain Therapeutic Antibody.” Technical Physics Letters, vol. 43, no. 12, Dec. 2017, pp. 1088-1091. https://doi.org/10.1134/S1063785017120045.
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