Development of a Novel Method for Activation of Isotope Exchange

The influence of various factors on the efficiency of introducing deuterium into 3-(N-pyrrolyl)-propanoyl-L-histidine and 3-(N-salicyl)-propanoyl-L-histidine was studied. Heavy water was used as a source of deuterium. It is shown that the content of deuterium atoms in the substance can be increased by pretreating the reaction mixture with deuterium gas. The new approach opens up additional possibilities both for obtaining high labeled pharmaceuticals by introducing hydrogen isotopes into organic compounds, and theoretically for a deeper understanding of the role in this process of activated deuterium or tritium particles solvated on the carrier and in the pool of matter.