Russian Journal of Bioorganic Chemistry

, том 36 , издание 3 , страницы 383-389

Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids

Тип публикации: Journal Article

Дата публикации: 2010-05-27

Pleiades Publishing

Russian Journal of Bioorganic Chemistry

scimago Q4

wos Q3

БС2

SJR: 0.267

CiteScore: 1.9

Impact factor: 1.7

ISSN: 10681620, 1608330X, 15739163

DOI: 10.1134/S1068162010030155

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PubMed ID: 20644598

Organic Chemistry

Biochemistry

Краткое описание

N-methylpyperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against Staphylococcus aureus at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against Klebsiella pneumoniae at a concentration of 60 mg/ml. Among the studied N-methylpyperazinyl amides, the highest activity against S. aureus was observed for a betulonic acid derivative.

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Kazakova O. B. et al. Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids // Russian Journal of Bioorganic Chemistry. 2010. Vol. 36. No. 3. pp. 383-389.

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Kazakova O. B., Giniyatullina G. V., Tolstikov G., Medvedeva N. I., Utkina T. M., Kartashova O. L. Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids // Russian Journal of Bioorganic Chemistry. 2010. Vol. 36. No. 3. pp. 383-389.

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TY - JOUR

DO - 10.1134/S1068162010030155

UR - https://doi.org/10.1134/S1068162010030155

TI - Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids

T2 - Russian Journal of Bioorganic Chemistry

AU - Kazakova, O B

AU - Giniyatullina, G V

AU - Tolstikov, G.A.

AU - Medvedeva, N. I.

AU - Utkina, T M

AU - Kartashova, O. L.

PY - 2010

DA - 2010/05/27

PB - Pleiades Publishing

SP - 383-389

IS - 3

VL - 36

PMID - 20644598

SN - 1068-1620

SN - 1608-330X

SN - 1573-9163

ER -

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@article{2010_Kazakova,

author = {O B Kazakova and G V Giniyatullina and G.A. Tolstikov and N. I. Medvedeva and T M Utkina and O. L. Kartashova},

title = {Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids},

journal = {Russian Journal of Bioorganic Chemistry},

year = {2010},

volume = {36},

publisher = {Pleiades Publishing},

month = {may},

url = {https://doi.org/10.1134/S1068162010030155},

number = {3},

pages = {383--389},

doi = {10.1134/S1068162010030155}

}

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Kazakova, O. B., et al. “Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids.” Russian Journal of Bioorganic Chemistry, vol. 36, no. 3, May. 2010, pp. 383-389. https://doi.org/10.1134/S1068162010030155.