DNA mimics based on pyrrolidine and hydroxyproline
Publication type: Journal Article
Publication date: 2010-11-18
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
PubMed ID:
21317938
Organic Chemistry
Biochemistry
Abstract
In recent years, a great number of analogues and mimics of nucleic acids have been developed with the aim of improving the physicochemical and biological properties of native oligonucleotides, in particular, to increase their affinity for nucleic acids, selectivity of action, and biological stability. This review summarizes the data on the synthesis and properties of DNA mimics, the analogues of peptide nucleic acids, which are the derivatives of pyrrolidine and hydroxyproline. Some physicochemical and biological properties of negatively charged mimics of this type are considered, which contain phosphonate residues in the back-bone and exhibit a high affinity for DNA and RNA, the selectivity of binding to nucleic acids, and stability in various biological systems. Examples of using these mimics as tools in molecular biology studies, in particular, functional genomics, are given. The prospects for their application in diagnosis and medicine are discussed.
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GOST
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Efimov V. A., Aralov A. V., Chakhmakhcheva O. G. DNA mimics based on pyrrolidine and hydroxyproline // Russian Journal of Bioorganic Chemistry. 2010. Vol. 36. No. 6. pp. 663-683.
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Efimov V. A., Aralov A. V., Chakhmakhcheva O. G. DNA mimics based on pyrrolidine and hydroxyproline // Russian Journal of Bioorganic Chemistry. 2010. Vol. 36. No. 6. pp. 663-683.
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RIS
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TY - JOUR
DO - 10.1134/S1068162010060014
UR - https://doi.org/10.1134/S1068162010060014
TI - DNA mimics based on pyrrolidine and hydroxyproline
T2 - Russian Journal of Bioorganic Chemistry
AU - Efimov, V A
AU - Aralov, A V
AU - Chakhmakhcheva, O G
PY - 2010
DA - 2010/11/18
PB - Pleiades Publishing
SP - 663-683
IS - 6
VL - 36
PMID - 21317938
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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BibTex (up to 50 authors)
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@article{2010_Efimov,
author = {V A Efimov and A V Aralov and O G Chakhmakhcheva},
title = {DNA mimics based on pyrrolidine and hydroxyproline},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2010},
volume = {36},
publisher = {Pleiades Publishing},
month = {nov},
url = {https://doi.org/10.1134/S1068162010060014},
number = {6},
pages = {663--683},
doi = {10.1134/S1068162010060014}
}
Cite this
MLA
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Efimov, V. A., et al. “DNA mimics based on pyrrolidine and hydroxyproline.” Russian Journal of Bioorganic Chemistry, vol. 36, no. 6, Nov. 2010, pp. 663-683. https://doi.org/10.1134/S1068162010060014.