Structure and stability of anionic liposomes complexes with PEG-chitosan branched copolymer
Publication type: Journal Article
Publication date: 2014-09-11
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
Application of branched copolymers of polyethylene glycol and chitosan (PEG-chitosan) as stabilizing agents for anionic liposomes was shown to improve considerably liposomes storage stability. In the course of the work, an efficient and convenient approach to synthesis of PEG-chitosan copolymers through chemical modification of chitosan amino groups with monomethoxy-PEG-N-hydroxysuccinimidyl succinate (mPEG-suc-NHS) was developed. Chitosan with varying degree of PEGylation were obtained and used as stabilizing agents for anionic liposomes prepared of dipalmitoylphosphatidylcholine-cardiolipin, 80/20 by weight. The molecular mechanism of complex formation between the anionic liposomes and PEG-chitosan was studied by methods of FTIR spectroscopy and dynamic light scattering. Phosphate and carbonyl groups were found to be the main sites of the aminopolysaccharide binding. Stabilization of the complexes is mainly achieved through electrostatic interactions between anionic groups of cardiolipin and free amino groups of PEG-chitosan. The method of liposome stabilization is promising for the development of new drug delivery systems.
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GOST
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Deygen I. M., Kudryashova E. V. Structure and stability of anionic liposomes complexes with PEG-chitosan branched copolymer // Russian Journal of Bioorganic Chemistry. 2014. Vol. 40. No. 5. pp. 547-557.
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Deygen I. M., Kudryashova E. V. Structure and stability of anionic liposomes complexes with PEG-chitosan branched copolymer // Russian Journal of Bioorganic Chemistry. 2014. Vol. 40. No. 5. pp. 547-557.
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RIS
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TY - JOUR
DO - 10.1134/S1068162014050057
UR - http://link.springer.com/10.1134/S1068162014050057
TI - Structure and stability of anionic liposomes complexes with PEG-chitosan branched copolymer
T2 - Russian Journal of Bioorganic Chemistry
AU - Deygen, I M
AU - Kudryashova, E V
PY - 2014
DA - 2014/09/11
PB - Pleiades Publishing
SP - 547-557
IS - 5
VL - 40
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Deygen,
author = {I M Deygen and E V Kudryashova},
title = {Structure and stability of anionic liposomes complexes with PEG-chitosan branched copolymer},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2014},
volume = {40},
publisher = {Pleiades Publishing},
month = {sep},
url = {http://link.springer.com/10.1134/S1068162014050057},
number = {5},
pages = {547--557},
doi = {10.1134/S1068162014050057}
}
Cite this
MLA
Copy
Deygen, I. M., and E V Kudryashova. “Structure and stability of anionic liposomes complexes with PEG-chitosan branched copolymer.” Russian Journal of Bioorganic Chemistry, vol. 40, no. 5, Sep. 2014, pp. 547-557. http://link.springer.com/10.1134/S1068162014050057.
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