Synthesis of (Z)-N-hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication
Publication type: Journal Article
Publication date: 2016-03-01
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
According to recently published results, cinnamic hydroxamic acid (CHA) inhibits replication of hepatitis C virus (HCV). We synthesized a structural analogue of CHA, i.e., (Z)-N-hydroxy-3-methoxy3-phenylacrylamide, which inhibited HCV replication five times more selectively than CHA. It was found that both compounds did not inhibit deacetylation of Ac-α-tubulin with histone deacetylase 6, the activity of which is important for virus replication.
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Kozlov M. V. et al. Synthesis of (Z)-N-hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication // Russian Journal of Bioorganic Chemistry. 2016. Vol. 42. No. 2. pp. 191-197.
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Kozlov M. V., Kleymenova A. A., Konduktorov K. A., Malikova A. Z., Kamarova K. A., Novikov R. A., Kochetkov S. N. Synthesis of (Z)-N-hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication // Russian Journal of Bioorganic Chemistry. 2016. Vol. 42. No. 2. pp. 191-197.
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TY - JOUR
DO - 10.1134/S1068162016010076
UR - https://doi.org/10.1134/S1068162016010076
TI - Synthesis of (Z)-N-hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication
T2 - Russian Journal of Bioorganic Chemistry
AU - Kozlov, M. V.
AU - Kleymenova, A A
AU - Konduktorov, K A
AU - Malikova, A Z
AU - Kamarova, K A
AU - Novikov, R A
AU - Kochetkov, S. N.
PY - 2016
DA - 2016/03/01
PB - Pleiades Publishing
SP - 191-197
IS - 2
VL - 42
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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@article{2016_Kozlov,
author = {M. V. Kozlov and A A Kleymenova and K A Konduktorov and A Z Malikova and K A Kamarova and R A Novikov and S. N. Kochetkov},
title = {Synthesis of (Z)-N-hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2016},
volume = {42},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134/S1068162016010076},
number = {2},
pages = {191--197},
doi = {10.1134/S1068162016010076}
}
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Kozlov, M. V., et al. “Synthesis of (Z)-N-hydroxy-3-methoxy-3-phenylacrylamide as new selective inhibitor of hepatitis C virus replication.” Russian Journal of Bioorganic Chemistry, vol. 42, no. 2, Mar. 2016, pp. 191-197. https://doi.org/10.1134/S1068162016010076.
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