Synthesis and pharmacological activity of 3-phenoxybenzoic acid derivatives
A.A. Spasov
1, 2
,
Yu. V. Popov
3
,
V S Lobasenko
3
,
T K Korchagina
3
,
P M Vassiliev
2
,
V A Kuznetsova
2
,
A A Brigadirova
1, 2
,
A I Rashchenko
2
,
D A Babkov
2
,
A N Kochetkov
2
,
A I Kovaleva
2
,
O S Efremova
3
1
Volgograd Medical Research Center, Volgograd, Russia
|
Тип публикации: Journal Article
Дата публикации: 2017-03-01
scimago Q4
wos Q3
БС2
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Краткое описание
New esters of N-benzoyl-3-phenoxyphenylcarboxamide acid and N-benzoyl-N′-4-bromophenyl-3-phenoxybenzamidine were synthesized. Some of the synthesized compounds were shown to inhibit the activity of dipeptidyl peptidase-4 and nonenzymatic glycosylation of proteins and manifested antiplatelet and antioxidant properties. The compounds tested did not display the antagonistic effect toward angiotensin II type 1 receptor, did not influence the activity of glycogen phosphorylase and had very little ability to break cross-links of the glycated proteins. The derivatives with the biological activity of two types were found, which can serve as basic molecules in the search for new drug products.
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ГОСТ
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Spasov A. et al. Synthesis and pharmacological activity of 3-phenoxybenzoic acid derivatives // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 2. pp. 163-169.
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Spasov A., Popov Y. V., Lobasenko V. S., Korchagina T. K., Vassiliev P. M., Kuznetsova V. A., Brigadirova A. A., Rashchenko A. I., Babkov D. A., Kochetkov A. N., Kovaleva A. I., Efremova O. S. Synthesis and pharmacological activity of 3-phenoxybenzoic acid derivatives // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 2. pp. 163-169.
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TY - JOUR
DO - 10.1134/S1068162017020145
UR - https://doi.org/10.1134/S1068162017020145
TI - Synthesis and pharmacological activity of 3-phenoxybenzoic acid derivatives
T2 - Russian Journal of Bioorganic Chemistry
AU - Spasov, A.A.
AU - Popov, Yu. V.
AU - Lobasenko, V S
AU - Korchagina, T K
AU - Vassiliev, P M
AU - Kuznetsova, V A
AU - Brigadirova, A A
AU - Rashchenko, A I
AU - Babkov, D A
AU - Kochetkov, A N
AU - Kovaleva, A I
AU - Efremova, O S
PY - 2017
DA - 2017/03/01
PB - Pleiades Publishing
SP - 163-169
IS - 2
VL - 43
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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@article{2017_Spasov,
author = {A.A. Spasov and Yu. V. Popov and V S Lobasenko and T K Korchagina and P M Vassiliev and V A Kuznetsova and A A Brigadirova and A I Rashchenko and D A Babkov and A N Kochetkov and A I Kovaleva and O S Efremova},
title = {Synthesis and pharmacological activity of 3-phenoxybenzoic acid derivatives},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2017},
volume = {43},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134/S1068162017020145},
number = {2},
pages = {163--169},
doi = {10.1134/S1068162017020145}
}
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MLA
Скопировать
Spasov, A.A., et al. “Synthesis and pharmacological activity of 3-phenoxybenzoic acid derivatives.” Russian Journal of Bioorganic Chemistry, vol. 43, no. 2, Mar. 2017, pp. 163-169. https://doi.org/10.1134/S1068162017020145.
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