Drug delivery systems for fluoroquinolones: New prospects in tuberculosis treatment
Publication type: Journal Article
Publication date: 2017-09-20
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
The review focuses on new delivery systems of fluoroquinolones, the highly active antibiotics, the therapeutic application of which is still limited due to low bioavailability and low solubility in biological media. The development of suitable delivery systems seems to be a promising solution to these problems. Here, we consider the delivery systems based on synthetic polymers (polylactic and polyglycolic acids and their copolymers, polycaprolactones, etc.) and natural polymers, in particular, polysaccharides. Oligosaccharide delivery systems, conjugates of fluoroquinolones with natural polymers, as well as lipid delivery systems, including liposomes, solid lipid particles, and hybrid particles, are also discussed. The characteristic features of oral, intravenous, and aerosol delivery methods for fluoroquinolones are revealed, which is especially important in the development of new drugs for the treatment of tuberculosis.
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GOST
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Le Deygen I. M., Skuredina A. A., Kudryashova E. V. Drug delivery systems for fluoroquinolones: New prospects in tuberculosis treatment // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 5. pp. 487-501.
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Le Deygen I. M., Skuredina A. A., Kudryashova E. V. Drug delivery systems for fluoroquinolones: New prospects in tuberculosis treatment // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 5. pp. 487-501.
Cite this
RIS
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TY - JOUR
DO - 10.1134/S1068162017050077
UR - https://doi.org/10.1134/S1068162017050077
TI - Drug delivery systems for fluoroquinolones: New prospects in tuberculosis treatment
T2 - Russian Journal of Bioorganic Chemistry
AU - Le Deygen, I M
AU - Skuredina, A A
AU - Kudryashova, E V
PY - 2017
DA - 2017/09/20
PB - Pleiades Publishing
SP - 487-501
IS - 5
VL - 43
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Le Deygen,
author = {I M Le Deygen and A A Skuredina and E V Kudryashova},
title = {Drug delivery systems for fluoroquinolones: New prospects in tuberculosis treatment},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2017},
volume = {43},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134/S1068162017050077},
number = {5},
pages = {487--501},
doi = {10.1134/S1068162017050077}
}
Cite this
MLA
Copy
Le Deygen, I. M., et al. “Drug delivery systems for fluoroquinolones: New prospects in tuberculosis treatment.” Russian Journal of Bioorganic Chemistry, vol. 43, no. 5, Sep. 2017, pp. 487-501. https://doi.org/10.1134/S1068162017050077.