Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy
P A Puchkov
1
,
I A Kartashova
1
,
A S Luneva
1
,
T O Kabilova
2
,
N G Morozova
1
,
M. A. Zenkova
2
,
Publication type: Journal Article
Publication date: 2017-09-20
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
Novel polycationic amphiphiles derived from triethylenetetramine, a spermine analogue, containing cholesterol or dialkylglycerol residues as hydrophilic domains were synthesized. The amphiphiles and a helper lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) served for the preparation of cationic liposomes, physicochemical properties of which were evaluated. A comparative study of cytotoxicity and transfection efficiency demonstrated that the replacement of spermine by triethylenetetramine decreased transfection activity of cationic liposomes.
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Puchkov P. A. et al. Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 5. pp. 561-569.
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Puchkov P. A., Perevoshchikova K. A., Kartashova I. A., Luneva A. S., Kabilova T. O., Morozova N. G., Zenkova M. A., Maslov M. A. Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy // Russian Journal of Bioorganic Chemistry. 2017. Vol. 43. No. 5. pp. 561-569.
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RIS
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TY - JOUR
DO - 10.1134/S1068162017050107
UR - http://link.springer.com/10.1134/S1068162017050107
TI - Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy
T2 - Russian Journal of Bioorganic Chemistry
AU - Puchkov, P A
AU - Perevoshchikova, K A
AU - Kartashova, I A
AU - Luneva, A S
AU - Kabilova, T O
AU - Morozova, N G
AU - Zenkova, M. A.
AU - Maslov, M A
PY - 2017
DA - 2017/09/20
PB - Pleiades Publishing
SP - 561-569
IS - 5
VL - 43
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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BibTex (up to 50 authors)
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@article{2017_Puchkov,
author = {P A Puchkov and K A Perevoshchikova and I A Kartashova and A S Luneva and T O Kabilova and N G Morozova and M. A. Zenkova and M A Maslov},
title = {Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2017},
volume = {43},
publisher = {Pleiades Publishing},
month = {sep},
url = {http://link.springer.com/10.1134/S1068162017050107},
number = {5},
pages = {561--569},
doi = {10.1134/S1068162017050107}
}
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Puchkov, P. A., et al. “Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy.” Russian Journal of Bioorganic Chemistry, vol. 43, no. 5, Sep. 2017, pp. 561-569. http://link.springer.com/10.1134/S1068162017050107.
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