The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids
Publication type: Journal Article
Publication date: 2018-01-01
scimago Q4
wos Q3
SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Abstract
New propargylamines were synthesized in 72–75% yields by the interaction of 19-alkynylbetulin and 28-O-propargyl glycinamide of oleanolic acid with N-methylpiperazine under the Mannich reaction conditions. 19-[1-Methyl-4-prop-2-yn-1-yl-piperazine]-20,29,30-trinorbetulin was shown to manifest anticancer activity against one line of leukemia cells and two lines of colon cancer cells, whereas the growth of leukemia cells SR in the presence of 4-(4-methylpiperazin-1-yl)but-2-yn-1-yl-N-(3-hydroxy-28-oxoolean-12-en-28-yl)glycinate was 8%.
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Total citations:
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Citations from 2025:
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(7.69%)
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GOST
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Khusnutdinova E. F. et al. The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids // Russian Journal of Bioorganic Chemistry. 2018. Vol. 44. No. 1. pp. 123-127.
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Khusnutdinova E. F., Apryshko G. N., Petrova A. V., Kukovinets O. S., Kazakova O. B. The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids // Russian Journal of Bioorganic Chemistry. 2018. Vol. 44. No. 1. pp. 123-127.
Cite this
RIS
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TY - JOUR
DO - 10.1134/S1068162018010090
UR - https://doi.org/10.1134/S1068162018010090
TI - The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids
T2 - Russian Journal of Bioorganic Chemistry
AU - Khusnutdinova, E F
AU - Apryshko, G N
AU - Petrova, A. V.
AU - Kukovinets, O S
AU - Kazakova, O B
PY - 2018
DA - 2018/01/01
PB - Pleiades Publishing
SP - 123-127
IS - 1
VL - 44
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
Cite this
BibTex (up to 50 authors)
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@article{2018_Khusnutdinova,
author = {E F Khusnutdinova and G N Apryshko and A. V. Petrova and O S Kukovinets and O B Kazakova},
title = {The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2018},
volume = {44},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134/S1068162018010090},
number = {1},
pages = {123--127},
doi = {10.1134/S1068162018010090}
}
Cite this
MLA
Copy
Khusnutdinova, E. F., et al. “The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids.” Russian Journal of Bioorganic Chemistry, vol. 44, no. 1, Jan. 2018, pp. 123-127. https://doi.org/10.1134/S1068162018010090.