Pleiades Publishing
Russian Journal of Bioorganic Chemistry
,  том 46 ,  издание 6 ,  страницы 1250-1260

Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids

Тип публикации: Journal Article
Дата публикации: 2020-11-01
Pleiades Publishing
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SJR: 0.267
CiteScore: 1.9
Impact factor: 1.7
ISSN: 10681620, 1608330X, 15739163
Organic Chemistry
Biochemistry
Краткое описание
New uncharged gemini-amphiphiles have been synthesized. A series of cationic liposomes based on the polycationic amphiphile 1,26-bis(cholest-5-en-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan tetrahydrochloride (2X3), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and uncharged gemini-amphiphiles that contain short hydrophobic and long hydrophilic spacers have been prepared. The physicochemical characteristics, cytotoxicity, and transfection activity of cationic liposomes have been studied. Cationic liposomes that include 10% (mol) of a uncharged gemini-amphiphile with the oligooxymethylene spacer have formed small complexes with plasmid DNA and efficiently delivered it into eukaryotic cells.
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Russian Journal of Bioorganic Chemistry
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Shmendel E. V. et al. Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids // Russian Journal of Bioorganic Chemistry. 2020. Vol. 46. No. 6. pp. 1250-1260.
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Shmendel E. V., Bakhareva S. A., Makarova D. M., Chernikov I. V., Morozova N. G., Chernolovskaya E. L., Zenkova M. A., Maslov M. A. Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids // Russian Journal of Bioorganic Chemistry. 2020. Vol. 46. No. 6. pp. 1250-1260.
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TY - JOUR
DO - 10.1134/S106816202006031X
UR - http://link.springer.com/10.1134/S106816202006031X
TI - Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids
T2 - Russian Journal of Bioorganic Chemistry
AU - Shmendel, E V
AU - Bakhareva, S A
AU - Makarova, D M
AU - Chernikov, I V
AU - Morozova, N G
AU - Chernolovskaya, E. L.
AU - Zenkova, M. A.
AU - Maslov, M A
PY - 2020
DA - 2020/11/01
PB - Pleiades Publishing
SP - 1250-1260
IS - 6
VL - 46
SN - 1068-1620
SN - 1608-330X
SN - 1573-9163
ER -
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@article{2020_Shmendel,
author = {E V Shmendel and S A Bakhareva and D M Makarova and I V Chernikov and N G Morozova and E. L. Chernolovskaya and M. A. Zenkova and M A Maslov},
title = {Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2020},
volume = {46},
publisher = {Pleiades Publishing},
month = {nov},
url = {http://link.springer.com/10.1134/S106816202006031X},
number = {6},
pages = {1250--1260},
doi = {10.1134/S106816202006031X}
}
MLA
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Shmendel, E. V., et al. “Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids.” Russian Journal of Bioorganic Chemistry, vol. 46, no. 6, Nov. 2020, pp. 1250-1260. http://link.springer.com/10.1134/S106816202006031X.
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