Russian Journal of Bioorganic Chemistry, volume 46, issue 6, pages 1250-1260

Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids

Shmendel E V ¹

Bakhareva S A ¹

Makarova D M ¹

Chernikov I V ²

Morozova N G ¹

Chernolovskaya E. L. ²

Zenkova M. A. ²

Maslov M A ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Lomonosov Institute of Fine Chemical Technologies, MIREA – Russian Technological University, Moscow, Russia |

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia |

Publication type: Journal Article

Publication date: 2020-11-01

Pleiades Publishing

Journal: Russian Journal of Bioorganic Chemistry

Quartile SCImago

Quartile WOS

Impact factor: 1

ISSN: 10681620, 1608330X

DOI: 10.1134/S106816202006031X

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Organic Chemistry

Biochemistry

Abstract

New uncharged gemini-amphiphiles have been synthesized. A series of cationic liposomes based on the polycationic amphiphile 1,26-bis(cholest-5-en-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan tetrahydrochloride (2X3), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and uncharged gemini-amphiphiles that contain short hydrophobic and long hydrophilic spacers have been prepared. The physicochemical characteristics, cytotoxicity, and transfection activity of cationic liposomes have been studied. Cationic liposomes that include 10% (mol) of a uncharged gemini-amphiphile with the oligooxymethylene spacer have formed small complexes with plasmid DNA and efficiently delivered it into eukaryotic cells.

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Russian Journal of Bioorganic Chemistry	Russian Journal of Bioorganic Chemistry, 1, 50% Russian Journal of Bioorganic Chemistry 1 publication, 50%
Pharmaceutics	Pharmaceutics, 1, 50% Pharmaceutics 1 publication, 50%
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Pleiades Publishing	Pleiades Publishing, 1, 50% Pleiades Publishing 1 publication, 50%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 50% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 50%
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Shmendel E. V. et al. Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids // Russian Journal of Bioorganic Chemistry. 2020. Vol. 46. No. 6. pp. 1250-1260.

GOST all authors (up to 50) Copy

Shmendel E. V., Bakhareva S. A., Makarova D. M., Chernikov I. V., Morozova N. G., Chernolovskaya E. L., Zenkova M. A., Maslov M. A. Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids // Russian Journal of Bioorganic Chemistry. 2020. Vol. 46. No. 6. pp. 1250-1260.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1134/S106816202006031X

UR - https://doi.org/10.1134%2FS106816202006031X

TI - Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids

T2 - Russian Journal of Bioorganic Chemistry

AU - Shmendel, E V

AU - Bakhareva, S A

AU - Makarova, D M

AU - Morozova, N G

AU - Zenkova, M. A.

AU - Maslov, M A

AU - Chernikov, I V

AU - Chernolovskaya, E. L.

PY - 2020

DA - 2020/11/01 00:00:00

PB - Pleiades Publishing

SP - 1250-1260

IS - 6

VL - 46

SN - 1068-1620

SN - 1608-330X

ER -

BibTex |

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BibTex Copy

@article{2020_Shmendel,

author = {E V Shmendel and S A Bakhareva and D M Makarova and N G Morozova and M. A. Zenkova and M A Maslov and I V Chernikov and E. L. Chernolovskaya},

title = {Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids},

journal = {Russian Journal of Bioorganic Chemistry},

year = {2020},

volume = {46},

publisher = {Pleiades Publishing},

month = {nov},

url = {https://doi.org/10.1134%2FS106816202006031X},

number = {6},

pages = {1250--1260},

doi = {10.1134/S106816202006031X}

}

MLA

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MLA Copy

Shmendel, E. V., et al. “Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids.” Russian Journal of Bioorganic Chemistry, vol. 46, no. 6, Nov. 2020, pp. 1250-1260. https://doi.org/10.1134%2FS106816202006031X.

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Publisher

Pleiades Publishing

Journal

Russian Journal of Bioorganic Chemistry

Quartile SCImago

Quartile WOS

Impact factor

ISSN

10681620 (Print)
1608330X (Electronic)

Labs

Laboratory of Lipids

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