Russian Journal of Bioorganic Chemistry, volume 47, issue 5, pages 965-979
Non-Phosphorus Lipids As New Antitumor Drug Prototypes
Publication type: Journal Article
Publication date: 2021-09-01
Quartile SCImago
Q4
Quartile WOS
Q4
Impact factor: 1
ISSN: 10681620, 1608330X
Organic Chemistry
Biochemistry
Abstract
The main classes of antitumor drugs (antimetabolites, anthracyclines, taxanes, and alkylating agents) act via DNA damage, inhibit DNA synthesis, and/or represent antimicrotubule agents. The phosphorus-containing alkyl glycerolipids induce death of tumor cells of various tissue origin, whereas nonmalignant counterparts are less damaged. One serious drawback of these compounds is their hemolytic activity, that is, disruption of red blood cells. Moreover, intracellular phospholipases can hydrolyze the phosphorus-containing glycerolipids and reduce their antitumor potency. This justifies the search for new antitumor, nonhemolytic phosphorus-free lipids. Modifications of the hydrophobic and polar groups yielded new lipid-based agents. In particular, the replacement of the hydrophilic phosphate group with a carbohydrate residue yielded a new chemotype of glycosylated glycerolipids. Further developments resulted in a series of non-phosphorus cationic, polycationic, and neutral glycoglycerolipids. New non-phosphorus lipids retained the antiproliferative and cytotoxic properties similarly to edelfosine and other alkyl phosphoglycerolipids. Importantly, the hemolytic activity was negligible or absent. This review analyzes the structure–activity relationship within the class of non-phosphorus glycerolipids as the original antitumor drug candidates.
Citations by journals
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Fine Chemical Technologies
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Fine Chemical Technologies
1 publication, 50%
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Molecules
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Molecules
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Citations by publishers
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RTU MIREA
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RTU MIREA
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 50%
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1
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Varlamova E. A. et al. Non-Phosphorus Lipids As New Antitumor Drug Prototypes // Russian Journal of Bioorganic Chemistry. 2021. Vol. 47. No. 5. pp. 965-979.
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Varlamova E. A., Isagulieva A. K., Morozova N. G., Shmendel E. V., Maslov M. A., Shtil A. A. Non-Phosphorus Lipids As New Antitumor Drug Prototypes // Russian Journal of Bioorganic Chemistry. 2021. Vol. 47. No. 5. pp. 965-979.
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TY - JOUR
DO - 10.1134/S1068162021050356
UR - https://doi.org/10.1134%2FS1068162021050356
TI - Non-Phosphorus Lipids As New Antitumor Drug Prototypes
T2 - Russian Journal of Bioorganic Chemistry
AU - Morozova, N G
AU - Maslov, M A
AU - Varlamova, E A
AU - Isagulieva, A K
AU - Shmendel, E V
AU - Shtil, A A
PY - 2021
DA - 2021/09/01 00:00:00
PB - Pleiades Publishing
SP - 965-979
IS - 5
VL - 47
SN - 1068-1620
SN - 1608-330X
ER -
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@article{2021_Varlamova,
author = {N G Morozova and M A Maslov and E A Varlamova and A K Isagulieva and E V Shmendel and A A Shtil},
title = {Non-Phosphorus Lipids As New Antitumor Drug Prototypes},
journal = {Russian Journal of Bioorganic Chemistry},
year = {2021},
volume = {47},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134%2FS1068162021050356},
number = {5},
pages = {965--979},
doi = {10.1134/S1068162021050356}
}
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MLA
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Varlamova, E. A., et al. “Non-Phosphorus Lipids As New Antitumor Drug Prototypes.” Russian Journal of Bioorganic Chemistry, vol. 47, no. 5, Sep. 2021, pp. 965-979. https://doi.org/10.1134%2FS1068162021050356.
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