Synthesis and Study of Antimicrobial Activity of Water-Soluble Ammonium Acylhydrazones Based on New 1,ω-Alkylenebis(isatins)
A. V. BOGDANOV
1
,
I F Zaripova
1
,
L K Mustafina
1
,
A D Voloshina
1
,
A S Sapunova
1
,
N V Kulik
1
,
Publication type: Journal Article
Publication date: 2019-07-01
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Abstract
Alkylation of isatin with 1,ω-dihaloalkanes afforded bis(heterocycles) connected by an oligomethylene linker. The reaction of the resulting bis(isatins) with Girard’s T and Girard’s P reagents led to the formation of symmetrical water-soluble acyl hydrazones with high yields. Evaluation of antimicrobial activity of new compounds showed the dependence of the activity level on the hydrocarbon spacer length. The selective activity of nona- and decamethylene derivatives was established with respect to gram-positive bacteria S. aureus 209p and B. cereus 8035. Low hematotoxicity of the obtained heterocycles was revealed.
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BOGDANOV A. V. et al. Synthesis and Study of Antimicrobial Activity of Water-Soluble Ammonium Acylhydrazones Based on New 1,ω-Alkylenebis(isatins) // Russian Journal of General Chemistry. 2019. Vol. 89. No. 7. pp. 1368-1376.
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BOGDANOV A. V., Zaripova I. F., Mustafina L. K., Voloshina A. D., Sapunova A. S., Kulik N. V., Mironov V. F. Synthesis and Study of Antimicrobial Activity of Water-Soluble Ammonium Acylhydrazones Based on New 1,ω-Alkylenebis(isatins) // Russian Journal of General Chemistry. 2019. Vol. 89. No. 7. pp. 1368-1376.
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RIS
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TY - JOUR
DO - 10.1134/S107036321907003X
UR - https://doi.org/10.1134/S107036321907003X
TI - Synthesis and Study of Antimicrobial Activity of Water-Soluble Ammonium Acylhydrazones Based on New 1,ω-Alkylenebis(isatins)
T2 - Russian Journal of General Chemistry
AU - BOGDANOV, A. V.
AU - Zaripova, I F
AU - Mustafina, L K
AU - Voloshina, A D
AU - Sapunova, A S
AU - Kulik, N V
AU - Mironov, V F
PY - 2019
DA - 2019/07/01
PB - Pleiades Publishing
SP - 1368-1376
IS - 7
VL - 89
SN - 1070-3632
SN - 1608-3350
ER -
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BibTex (up to 50 authors)
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@article{2019_BOGDANOV,
author = {A. V. BOGDANOV and I F Zaripova and L K Mustafina and A D Voloshina and A S Sapunova and N V Kulik and V F Mironov},
title = {Synthesis and Study of Antimicrobial Activity of Water-Soluble Ammonium Acylhydrazones Based on New 1,ω-Alkylenebis(isatins)},
journal = {Russian Journal of General Chemistry},
year = {2019},
volume = {89},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134/S107036321907003X},
number = {7},
pages = {1368--1376},
doi = {10.1134/S107036321907003X}
}
Cite this
MLA
Copy
BOGDANOV, A. V., et al. “Synthesis and Study of Antimicrobial Activity of Water-Soluble Ammonium Acylhydrazones Based on New 1,ω-Alkylenebis(isatins).” Russian Journal of General Chemistry, vol. 89, no. 7, Jul. 2019, pp. 1368-1376. https://doi.org/10.1134/S107036321907003X.