Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
D S Buryi
1
,
V V Dotsenko
1, 2, 3
,
N A Aksenov
2
,
I V Aksenova
2
,
S G Krivokolysko
3, 4
,
L V Dyadyuchenko
5
3
KhimEks Laboratory, Vladimir Dahl Lugansk National University, Lugansk, Ukraine
|
Publication type: Journal Article
Publication date: 2019-08-01
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Abstract
The reaction of 3-pentylpentane-2,4-dione with cyanothioacetamide afforded 4,6-dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile. Alkylation of the latter led to the formation of 2-alkylsulfanyl-4,6-dimethyl-5-pentylpyridine-3-carbonitriles or 3-amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines, depending on the alkylating agent and reaction conditions. The structures of the key compounds were proved by 2D NMR spectroscopy and X-ray analysis. Biological activity of the synthesized compounds was evaluated in silico. Some compounds were experimentally found to stimulate growth of sunflower seedlings.
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Total citations:
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Citations from 2024:
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(36.85%)
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Buryi D. S. et al. Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines // Russian Journal of General Chemistry. 2019. Vol. 89. No. 8. pp. 1575-1585.
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Buryi D. S., Dotsenko V. V., Aksenov N. A., Aksenova I. V., Krivokolysko S. G., Dyadyuchenko L. V. Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines // Russian Journal of General Chemistry. 2019. Vol. 89. No. 8. pp. 1575-1585.
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RIS
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TY - JOUR
DO - 10.1134/s1070363219080061
UR - https://doi.org/10.1134/s1070363219080061
TI - Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines
T2 - Russian Journal of General Chemistry
AU - Buryi, D S
AU - Dotsenko, V V
AU - Aksenov, N A
AU - Aksenova, I V
AU - Krivokolysko, S G
AU - Dyadyuchenko, L V
PY - 2019
DA - 2019/08/01
PB - Pleiades Publishing
SP - 1575-1585
IS - 8
VL - 89
SN - 1070-3632
SN - 1608-3350
ER -
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BibTex (up to 50 authors)
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@article{2019_Buryi,
author = {D S Buryi and V V Dotsenko and N A Aksenov and I V Aksenova and S G Krivokolysko and L V Dyadyuchenko},
title = {Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines},
journal = {Russian Journal of General Chemistry},
year = {2019},
volume = {89},
publisher = {Pleiades Publishing},
month = {aug},
url = {https://doi.org/10.1134/s1070363219080061},
number = {8},
pages = {1575--1585},
doi = {10.1134/s1070363219080061}
}
Cite this
MLA
Copy
Buryi, D. S., et al. “Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines.” Russian Journal of General Chemistry, vol. 89, no. 8, Aug. 2019, pp. 1575-1585. https://doi.org/10.1134/s1070363219080061.