1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
V V Dotsenko
1, 2
,
A N Khrustaleva
3
,
K A Frolov
1
,
N A Aksenov
2
,
I V Aksenova
2
,
S G Krivokolysko
1
Publication type: Journal Article
Publication date: 2021-01-01
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Abstract
Abstract 1,6-Diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles under the action of primary aliphatic amines and an excess of 37% formalin in ethanol were converted into 2,3,8,9-tetrahydro-6,10-methano[1,2,4]triazolo[1,5- a ][1,5]diazocine-6,10(7 H )-dicarbonitrile derivatives. At the same time, the Mannich reaction in the case of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles proceeds ambiguously, and, depending on the conditions, gives either N-ethoxymethylation products or 1,2,4-triazolo[1,5- a ]pyridine derivatives. In silico predictive analysis of the biological activity of new compounds was carried out.
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Total citations:
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Citations from 2024:
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(33.33%)
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Dotsenko V. V. et al. 1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction // Russian Journal of General Chemistry. 2021. Vol. 91. No. 1. pp. 44-56.
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Dotsenko V. V., Khrustaleva A. N., Frolov K. A., Aksenov N. A., Aksenova I. V., Krivokolysko S. G. 1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction // Russian Journal of General Chemistry. 2021. Vol. 91. No. 1. pp. 44-56.
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TY - JOUR
DO - 10.1134/S1070363221010047
UR - https://doi.org/10.1134/S1070363221010047
TI - 1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction
T2 - Russian Journal of General Chemistry
AU - Dotsenko, V V
AU - Khrustaleva, A N
AU - Frolov, K A
AU - Aksenov, N A
AU - Aksenova, I V
AU - Krivokolysko, S G
PY - 2021
DA - 2021/01/01
PB - Pleiades Publishing
SP - 44-56
IS - 1
VL - 91
SN - 1070-3632
SN - 1608-3350
ER -
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BibTex (up to 50 authors)
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@article{2021_Dotsenko,
author = {V V Dotsenko and A N Khrustaleva and K A Frolov and N A Aksenov and I V Aksenova and S G Krivokolysko},
title = {1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction},
journal = {Russian Journal of General Chemistry},
year = {2021},
volume = {91},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134/S1070363221010047},
number = {1},
pages = {44--56},
doi = {10.1134/S1070363221010047}
}
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MLA
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Dotsenko, V. V., et al. “1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction.” Russian Journal of General Chemistry, vol. 91, no. 1, Jan. 2021, pp. 44-56. https://doi.org/10.1134/S1070363221010047.