Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives
I V Bibik
1
,
E Yu Bibik
2
,
V V Dotsenko
2, 3
,
K A Frolov
2
,
S G Krivokolysko
2
,
N A Aksenov
3
,
I V Aksenova
3
,
S V Shcherbakov
3
,
S N Ovcharov
3
Publication type: Journal Article
Publication date: 2021-02-01
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Abstract
The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series of heterocyclic derivatives with a 1,2,3,4-tetrahydropyridine or 1,4,5,6,7,8-hexahydroquinoline fragment. The resulting compounds were tested for analgesic activity in vivo. Some of the prepared compounds showed an antinociceptive effect superior to that of ketorolac in dynamics.
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18
Total citations:
18
Citations from 2024:
7
(38.89%)
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GOST
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Bibik I. V. et al. Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives // Russian Journal of General Chemistry. 2021. Vol. 91. No. 2. pp. 154-166.
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Bibik I. V., Bibik E. Yu., Dotsenko V. V., Frolov K. A., Krivokolysko S. G., Aksenov N. A., Aksenova I. V., Shcherbakov S. V., Ovcharov S. N. Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives // Russian Journal of General Chemistry. 2021. Vol. 91. No. 2. pp. 154-166.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/s107036322102002x
UR - https://doi.org/10.1134/s107036322102002x
TI - Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives
T2 - Russian Journal of General Chemistry
AU - Bibik, I V
AU - Bibik, E Yu
AU - Dotsenko, V V
AU - Frolov, K A
AU - Krivokolysko, S G
AU - Aksenov, N A
AU - Aksenova, I V
AU - Shcherbakov, S V
AU - Ovcharov, S N
PY - 2021
DA - 2021/02/01
PB - Pleiades Publishing
SP - 154-166
IS - 2
VL - 91
SN - 1070-3632
SN - 1608-3350
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Bibik,
author = {I V Bibik and E Yu Bibik and V V Dotsenko and K A Frolov and S G Krivokolysko and N A Aksenov and I V Aksenova and S V Shcherbakov and S N Ovcharov},
title = {Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives},
journal = {Russian Journal of General Chemistry},
year = {2021},
volume = {91},
publisher = {Pleiades Publishing},
month = {feb},
url = {https://doi.org/10.1134/s107036322102002x},
number = {2},
pages = {154--166},
doi = {10.1134/s107036322102002x}
}
Cite this
MLA
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Bibik, I. V., et al. “Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives.” Russian Journal of General Chemistry, vol. 91, no. 2, Feb. 2021, pp. 154-166. https://doi.org/10.1134/s107036322102002x.