New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity
D S Krivokolysko
1
,
Viktor V Dotsenko
2, 3
,
Elena Yu. Bibik
1
,
A A Samokish
1
,
Yu S Venidiktova
1
,
Konstantin A. Frolov
4
,
V K Vasilin
5
,
A A Pankov
4
,
4
V. Dahl Lugansk State University, Lugansk, Ukraine
|
Тип публикации: Journal Article
Дата публикации: 2021-09-01
scimago Q4
wos Q4
БС2
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Краткое описание
A series of new hybrid molecules containing 2-furyl and partially saturated pyridine fragments was obtained based on the reaction of cyanothioacetamide with furfural and 1,3-dicarbonyl compounds. The resulting compounds were tested in vivo for analgesic activity (rats) in the orofacial trigeminal pain test. Some the tested compounds showed an antinociceptive effect, superior to that of the reference drug (metamizole sodium).
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Krivokolysko D. S. et al. New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity // Russian Journal of General Chemistry. 2021. Vol. 91. No. 9. pp. 1646-1660.
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Krivokolysko D. S., Dotsenko V. V., Bibik E. Y., Samokish A. A., Venidiktova Yu. S., Frolov K. A., Krivokolysko S. G., Vasilin V. K., Pankov A. A., Aksenov N. A., Aksenova I. V. New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity // Russian Journal of General Chemistry. 2021. Vol. 91. No. 9. pp. 1646-1660.
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TY - JOUR
DO - 10.1134/s1070363221090073
UR - https://doi.org/10.1134/s1070363221090073
TI - New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity
T2 - Russian Journal of General Chemistry
AU - Krivokolysko, D S
AU - Dotsenko, Viktor V
AU - Bibik, Elena Yu.
AU - Samokish, A A
AU - Venidiktova, Yu S
AU - Frolov, Konstantin A.
AU - Krivokolysko, Sergey G.
AU - Vasilin, V K
AU - Pankov, A A
AU - Aksenov, Nicolai A.
AU - Aksenova, I V
PY - 2021
DA - 2021/09/01
PB - Pleiades Publishing
SP - 1646-1660
IS - 9
VL - 91
SN - 1070-3632
SN - 1608-3350
ER -
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@article{2021_Krivokolysko,
author = {D S Krivokolysko and Viktor V Dotsenko and Elena Yu. Bibik and A A Samokish and Yu S Venidiktova and Konstantin A. Frolov and Sergey G. Krivokolysko and V K Vasilin and A A Pankov and Nicolai A. Aksenov and I V Aksenova},
title = {New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity},
journal = {Russian Journal of General Chemistry},
year = {2021},
volume = {91},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134/s1070363221090073},
number = {9},
pages = {1646--1660},
doi = {10.1134/s1070363221090073}
}
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Krivokolysko, D. S., et al. “New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity.” Russian Journal of General Chemistry, vol. 91, no. 9, Sep. 2021, pp. 1646-1660. https://doi.org/10.1134/s1070363221090073.