Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters
D S Krivokolysko
1
,
Viktor V Dotsenko
2, 3
,
Elena Yu. Bibik
1
,
A V Myazina
1
,
V K Vasilin
5
,
A A Pankov
4
,
4
V. Dahl Lugansk State University, Lugansk, Ukraine
|
Publication type: Journal Article
Publication date: 2021-12-01
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Abstract
A series of new hybrid molecules containing fragments of anestesin and 4-(2-furyl)-1,4-dihydronicotinonitrile have been obtained starting from diketene, ethyl 4-aminobenzoate, cyanothioacetamide, and furfural. The obtained compounds have been investigated for the analgesic activity in vivo (rats) in the orofacial trigeminal pain and acetic acid induced writhing tests. The compounds exhibiting analgesic effect superior to that of the reference drug (metamizole sodium) have been revealed. Molecular docking has been performed for the considered compounds with respect to a wide range of protein targets, including cyclooxygenases COX-1 and COX-2.
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11
Total citations:
11
Citations from 2024:
5
(45.45%)
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Krivokolysko D. S. et al. Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters // Russian Journal of General Chemistry. 2021. Vol. 91. No. 12. pp. 2588-2605.
GOST all authors (up to 50)
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Krivokolysko D. S., Dotsenko V. V., Bibik E. Y., Myazina A. V., Krivokolysko S. G., Vasilin V. K., Pankov A. A., Aksenov N. A., Aksenova I. V. Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters // Russian Journal of General Chemistry. 2021. Vol. 91. No. 12. pp. 2588-2605.
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RIS
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TY - JOUR
DO - 10.1134/s1070363221120306
UR - https://doi.org/10.1134/s1070363221120306
TI - Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters
T2 - Russian Journal of General Chemistry
AU - Krivokolysko, D S
AU - Dotsenko, Viktor V
AU - Bibik, Elena Yu.
AU - Myazina, A V
AU - Krivokolysko, Sergey G.
AU - Vasilin, V K
AU - Pankov, A A
AU - Aksenov, Nicolai A.
AU - Aksenova, Inna V.
PY - 2021
DA - 2021/12/01
PB - Pleiades Publishing
SP - 2588-2605
IS - 12
VL - 91
SN - 1070-3632
SN - 1608-3350
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_Krivokolysko,
author = {D S Krivokolysko and Viktor V Dotsenko and Elena Yu. Bibik and A V Myazina and Sergey G. Krivokolysko and V K Vasilin and A A Pankov and Nicolai A. Aksenov and Inna V. Aksenova},
title = {Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters},
journal = {Russian Journal of General Chemistry},
year = {2021},
volume = {91},
publisher = {Pleiades Publishing},
month = {dec},
url = {https://doi.org/10.1134/s1070363221120306},
number = {12},
pages = {2588--2605},
doi = {10.1134/s1070363221120306}
}
Cite this
MLA
Copy
Krivokolysko, D. S., et al. “Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters.” Russian Journal of General Chemistry, vol. 91, no. 12, Dec. 2021, pp. 2588-2605. https://doi.org/10.1134/s1070363221120306.