Synthesis and Antinociceptive Activity of Substituted Derivatives of Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo-[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates
Тип публикации: Journal Article
Дата публикации: 2024-05-01
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CiteScore: 1.6
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ISSN: 10703632, 16083350
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А series of new substituted potassium 1-cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates was synthesised by the ring opening reaction of substituted 2-{[2-oxo-5-arylfuran-3(2H)-ylidene]amino}-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles under the action of cyanoacetic acid derivatives and potassium tert-butoxide. Antinociceptive activity and acute toxicity of the obtained compounds were investigated by in vivo experiments. It was found that the obtained substituted potassium salts possess pronounced antinociceptive activity and are practically non-toxic drugs.
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KOZLOV D. A. et al. Synthesis and Antinociceptive Activity of Substituted Derivatives of Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo-[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates // Russian Journal of General Chemistry. 2024. Vol. 94. No. 5. pp. 1024-1030.
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KOZLOV D. A., Lipin D. V., Gorbunova I. A., Shipilovskikh D. A., Timin A. S., Silaichev P. S., Makhmudov R. R., Shadrin V. M., Shipilovskikh S. A. Synthesis and Antinociceptive Activity of Substituted Derivatives of Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo-[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates // Russian Journal of General Chemistry. 2024. Vol. 94. No. 5. pp. 1024-1030.
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TY - JOUR
DO - 10.1134/s1070363224050025
UR - https://link.springer.com/10.1134/S1070363224050025
TI - Synthesis and Antinociceptive Activity of Substituted Derivatives of Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo-[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates
T2 - Russian Journal of General Chemistry
AU - KOZLOV, D. A.
AU - Lipin, D V
AU - Gorbunova, I A
AU - Shipilovskikh, D A
AU - Timin, A S
AU - Silaichev, P S
AU - Makhmudov, R R
AU - Shadrin, V M
AU - Shipilovskikh, S A
PY - 2024
DA - 2024/05/01
PB - Pleiades Publishing
SP - 1024-1030
IS - 5
VL - 94
SN - 1070-3632
SN - 1608-3350
ER -
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@article{2024_KOZLOV,
author = {D. A. KOZLOV and D V Lipin and I A Gorbunova and D A Shipilovskikh and A S Timin and P S Silaichev and R R Makhmudov and V M Shadrin and S A Shipilovskikh},
title = {Synthesis and Antinociceptive Activity of Substituted Derivatives of Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo-[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates},
journal = {Russian Journal of General Chemistry},
year = {2024},
volume = {94},
publisher = {Pleiades Publishing},
month = {may},
url = {https://link.springer.com/10.1134/S1070363224050025},
number = {5},
pages = {1024--1030},
doi = {10.1134/s1070363224050025}
}
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KOZLOV, D. A., et al. “Synthesis and Antinociceptive Activity of Substituted Derivatives of Potassium 1-Cyano-3-{(3-cyano-4,5,6,7-tetrahydrobenzo-[b]thiophen-2-yl)amino}-5-oxopenta-1,3-dien-2-olates.” Russian Journal of General Chemistry, vol. 94, no. 5, May. 2024, pp. 1024-1030. https://link.springer.com/10.1134/S1070363224050025.
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